Last Updated on February 1, 2023 by
A person struggling with side effects of Effexor® or experiencing a lack of efficacy of the medication may not have been informed of safer alternatives. It is well-established that SNRI antidepressants like Effexor can cause side effects that outweigh the benefits of continuing to take them.1,4
The withdrawal effects that occur when stopping a serotonin-norepinephrine re-uptake inhibiting drug like Effexor can be daunting, and one should never stop taking this drug abruptly. However, with guidance, a person can gradually come off the drug safely and may benefit by transitioning to Effexor alternatives. Based on our research and direct clinical experience, we know other possibilities exist besides living a lifetime medicated on antidepressant drugs. Do you wish to start living life in a way that resembles your desired self without Effexor side effects?
In many cases, Effexor may not adequately treat symptoms.18 Effexor (venlafaxine) has a very short half-life, approximately 5 hours.19 This means a late or missed dose can cause grievous problems, resulting in time lost at work, injuries and accidents, and other negative consequences.20 As mentioned above, serious harm to health can occur because of potentially life-threatening Effexor side effects that many persons experience.4 For all of these reasons, one may begin to consider safe and effective Effexor alternatives for improvements in mental wellness. The bottom line is if this antidepressant medication is not working as it should or if you are experiencing unwanted side effects, talk with your doctor, and talk to us, about alternatives to Effexor.
*Isa Kay writes in The University of Michigan School of Public Health newsletter that eating low glycemic foods such as proteins can help stabilize both blood sugar and moods.
There are a host of possible factors besides an Effexor deficiency that can bring on feelings of depression. There are many medical reasons and life situations that can contribute to depression that our integrative methodologies are designed to discover and treat with Effexor alternatives.
According to truckloads of medical literature, depression is an extremely common problem in today’s world.27 The term is used to describe a type of mental illness that apparently millions upon millions of people suffer from. There are alternative health practitioners who have looked at the problem closely and are not convinced that we are looking at a mysterious mental illness at all and that the widened set of symptoms cast by the DSM, echoed by pharmaceutical giants, has netted a wider population than fits the suggested criteria.28 We are looking at an actual problem but we don’t all agree that the best answer will come from a pharmaceutical drug.5,29 Mainstream medicine attempts to treat depression with antidepressant medications. But because they don’t always “work,” and because they also create unwanted side effects of their own,18 many people have begun seeking natural antidepressant alternatives for their depression. Some people may seek alternatives after they have tried traditional depression (drug-based) treatments and have been non-responsive to them or intolerable to side effects. Other people are simply looking for non-chemical, natural ways to treat depression.
No matter what the reason is for desiring Effexor alternatives for depression, fortunately, there is a whole host of alternative Effexor options. These can be “stand-alone” or can be used in conjunction with other strategies and alternative therapies. Talk therapies are proven to be very effective alternatives for treating depression. 30 During a talk therapy session, patients are able to gain insight from an objective person and often are able to work through their problems through meaningful verbal exchange with their talk therapist.
Many talk therapy sessions also include homework assignments to practice in the real world between sessions. Talk therapists and behavioral therapists help their patients to learn how they can obtain more satisfaction and reward from their own actions and words, and their lifestyle choices. It can be an enlightening experience to learn how to recognize and undo negative and/or unhealthy behavioral patterns. Changing the contributors to depression can help to lessen their feelings of despondency, dissatisfaction, or hopelessness in their life. And all that without a pill bottle in sight.
Depression can also be attributed to a lack of nutrients or deficiencies in certain vitamins that our bodies need to function at their full capability; mentally and physically. Diet can be instrumental in treatment.31 Another aspect of antidepressant alternatives for depression includes natural medicine such as vitamins, herbs, remedies, dietary supplements, minerals, and naturally occurring substances that are healthy for the body and mind. Valerian, Kava, St. Johns Wort, omega-3 essential fatty acids, SAMe (S-adenosyl-L-methionine), vitamin B6 and all the vitamins found in food or that can be supplemented, 5-HTP (5-hydroxytryptophan), extracts of curcumin and saffron, are some of the commonly used supplements used in the natural treatment of depression. Dietary changes, as well as effective supplementation, can provide effective Effexor tapering alternatives.31,32,40
Acupuncture is a popular, feel-good, and effective method of therapy for depression. Depression can sometimes be a result of suppressing feelings of sadness, anger, or embarrassment rather than expressing these feelings and letting them go. Acupuncturists use the surface of the body to connect to the inner body and mind to unblock repressed energy that can be contributing to depression. Once this blocked, repressed, negative energy is released; the person may experience relief as these negative energies come up to the surface. Acupuncture sessions usually leave a person feeling elevated in mood, refreshed, and empowered.33,44
Drug companies push the idea hard that depression is caused by not taking drugs, not taking enough drugs, and not taking the “right” drugs.3 However, we want to discover root causes and treat them. Alternative therapies for Effexor cover a very broad range of actual causes for depressed mood, chronic anger, and other undesirable symptoms that Effexor is often prescribed to “treat.” We should listen to our symptoms, and treat them in ways that do not lay in further harm, especially to a person whose health is already in a fragile condition. Acupuncture, talk therapy, vitamin/nutritional therapy, and many other Effexor alternatives make effective strategies in treating symptoms of depression without drugs. Additional therapies include aromatherapy, massage therapy, reflexology, yoga, meditation, and exercise. And, we really cannot overemphasize the fact that nutrients can be fundamental in regulating neurochemistry, and how significantly that can benefit mental health naturally.31
There is much to discover about effectively reducing unwanted symptoms, especially without introducing potentially harmful drugs into the picture. When one realizes the possible injurious results of pharmaceutical drugs, natural alternatives become a logical and welcome choice.2
Where drugs have already been introduced and found lacking in efficacy, we can help transition to drug-free, healthy living via natural Effexor withdrawal therapies. We invite you to contact us at Alternative to Meds for more information on how we may be able to guide you or a loved one with Effexor alternatives in improving mental health naturally.
1. Rubino A, Roskell N, Tennis P, Mines D, Welch S, Andrews E, “Venlafaxine Associated With Increased Risk of Suicide and Attempted Suicide.” The Formulary Watch [Internet] 2007 May 1 [cited 2022 June 13]
2. PharmTech authors FDA Warns Wyeth About Effexor Ad [published online Dec 20,2007] [cited 2022 June 13]
3. Hosseini F, Amini F, Mojtaba Y, Ardekani Y, Shariat N, Nadi M, “Double-Blind Randomized Clinical Trial of the Efficacy of Venlafaxine Versus Citalopram in the Treatment of the Acute Phase of Major Depressive Disorder.” Iranian Journal of Psychiatry and Behavioral Sciences [Internet] 2015 Jun 1 [cited 2022 June 13]
4. Pfizer Patient Information Effexor XR Product Template [published online] [cited 2022 June 13]
5. Breggin P, “SSRI and Other Antidepressants Page.” Psychiatric Drug Facts blog [Internet] [cited 2022 June 13]
6. Is Your Mood Disorder a Symptom of Unstable Blood Sugar? University of Michigan School of Public Health [online] by Isa Kay October 21, 2019 [cited 2022 June 13]
18. The drugs don’t work? antidepressants and the current and future pharmacological management of depression Ther Adv Psychopharmacol. 2012 Oct; 2(5): 179–188. Elizabeth Penncor responding author and Derek K. Tracy [cited 2022 June 13]
19 FDA Label Effexor XR Section 12.3 [Revised Jan 2017] [cited 2022 June 13]
20. Campangne D, “Venlafaxine and Serious Withdrawal Symptoms: Warning to Drivers.” MedGenMed [online] 2005 July 6 [cited 2022 June 13]
21. Xie Z, Chen F, Li WA, Geng X, Li C, Meng X, Feng Y, Liu W, Yu F. “A review of sleep disorders and melatonin.” Neurol Res. 2017 Jun;39(6):559-565. doi: 10.1080/01616412.2017.1315864. Epub 2017 May 1. PMID: 28460563 [cited 2022 June 13]
22. Brown JS Jr. “Psychiatric issues in toxic exposures.” Psychiatr Clin North Am. 2007 Dec;30(4):837-54. doi: 10.1016/j.psc.2007.07.004. PMID: 17938048. [cited 2022 June 13]
23. Touret M, Sarda N, Gharib A, Geffard M, Jouvet M. “The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study.” Exp Brain Res. 1991;86(1):117-24. doi: 10.1007/BF00231046. PMID: 1836762. [cited 2022 June 13]
24. Carbajo J, Maraver F, “Sulphurous Mineral Waters: New Applications for Health.” Evid Based Complement Alternat Med. [online] April 6, 2017 PMID 28484507 [cited 2022 June 13]
25. Mikkelsen K, Stojanovska L, Polenakovic M, Bosevski M, Apostolopoulos V. Exercise and mental health. Maturitas. 2017 Dec;106:48-56. doi: 10.1016/j.maturitas.2017.09.003. Epub 2017 Sep 7. PMID: 29150166. [cited 2022 June 13]
26. Knippenberg S, Damoiseaux J, Bol Y, Hupperts R, Taylor BV, Ponsonby AL, Dwyer T, Simpson S, van der Mei IA. Higher levels of reported sun exposure, and not vitamin D status, are associated with less depressive symptoms and fatigue in multiple sclerosis. Acta Neurol Scand. 2014 Feb;129(2):123-31. doi: 10.1111/ane.12155. Epub 2013 Jun 13. PMID: 23763464. [cited 2022 June 13]
27. Malhl G, Mann J, “Depression: Summary” The Lancet [online November 2, 2018] [cited 2022 June 13]
28. Horwitz A, “How an Age of Anxiety Became an Age of Depression.” The Milbank Quarterly, March 2010 PMID 20377760 [cited 2022 June 13]
29. van der Watt G, Laugharne J, Janca A. “Complementary and alternative medicine in the treatment of anxiety and depression.” Curr Opin Psychiatry. 2008 Jan;21(1):37-42. doi: 10.1097/YCO.0b013e3282f2d814. PMID: 18281839.cited 2022 June 13]
30. Hoffman S et al., “The Efficacy of Cognitive Behavioral Therapy: A Review of Meta-Analyses.” Cognit Ther Res. 2012 Oct 1; 36(5): 427-440 [online] PMID 23459093 [cited 2022 June 13]
31. Low Dog T. “The role of nutrition in mental health.” Altern Ther Health Med. 2010 Mar-Apr;16(2):42-6. PMID: 20232617. [cited 2022 June 13]
32. Hvas AM, Juul S, Bech P, Nexø E. “Vitamin B6 level is associated with symptoms of depression.” Psychother Psychosom. 2004 Nov-Dec;73(6):340-3. doi: 10.1159/000080386. PMID: 15479988. [cited 2022 June 13]
33. Smith CA, Armour M, Lee MS, Wang LQ, Hay PJ. “Acupuncture for depression.” Cochrane Database Syst Rev. 2018 Mar 4;3(3):CD004046. doi: 10.1002/14651858.CD004046.pub4. PMID: 29502347; PMCID: PMC6494180. [cited 2022 June 13]
34. American Academy of Sleep Medicine Healthy Sleep Habits Updated Feb. 9, 2017 cited 2022 June 13]
35. Mold Warriors: Fighting America’s Hidden Health Threat Paperback– April 1, 2005 by Ritchie C. Shoemaker (Author), James Schaller (Author), Patti Schmidt (Author) [cited 2022 June 13]
36. Nicholas J. Heyer, Diana Echeverria, Alvah C. Bittner, Jr., Federico M. Farin, Claire C. Garabedian, James S. Woods, Chronic Low-Level Mercury Exposure, BDNF Polymorphism, and Associations with Self-Reported Symptoms and Mood,Toxicological Sciences, Volume 81, Issue 2, October 2004, Pages 354–363. [cited 2022 June 13]
37. Orisakwe OE. The role of lead and cadmium in psychiatry.N Am J Med Sci. 2014;6(8):370-376. doi:10.4103/1947-2714.139283. [cited 2022 June 13]
38. Craft LL, Perna FM. The Benefits of Exercise for the Clinically Depressed. Prim Care Companion J Clin Psychiatry. 2004;6(3):104-111. doi:10.4088/pcc.v06n0301 cited 2022 June 13]
39. “CBT Better than Medication For Treating Social Anxiety Disorder.” The Psychiatry Advisor [Internet] 2014 Sep 26 [cited 2022 June 13]
40. Jade, Kathleen ND “Two Natural Antidepressants Found to be as Effective as Prozac” University Health News [INTERNET] 2019 Mar [cited 2022 June 13]
41. Furuyashiki A, Tabuchi K, Norikoshi K, Kobayashi T, Oriyama S. A comparative study of the physiological and psychological effects of forest bathing(Shinrin-yoku) on working age people with and without depressive tendencies. Environ Health Prev Med. 2019 Jun 22;24(1):46. doi: 10.1186/s12199-019-0800-1. PMID: 31228960; PMCID: PMC6589172. [cited 2022 June 13]
42. Foster JA, McVey Neufeld KA. Gut-brain axis: how the microbiome influences anxiety and depression. Trends Neurosci. 2013 May;36(5):305-12. doi: 10.1016/j.tins.2013.01.005. Epub 2013 Feb 4. PMID: 23384445. [cited 2022 June 13]
43. Sniezek, D. P., & Siddiqui, I. J. (2013). Acupuncture for Treating Anxiety and Depression in Women: A Clinical Systematic Review.Medical acupuncture, 25(3), 164–172. https://doi.org/10.1089/acu.2012.0900. [cited 2022 June 13]
44. Yeung WF, Yu BY, Yuen JW, Ho JYS, Chung KF, Zhang ZJ, Mak DSY, Suen LK, Ho LM. Semi-Individualized Acupuncture for Insomnia Disorder and Oxidative Stress: A Randomized, Double-Blind, Sham-Controlled Trial. Nat Sci Sleep. 2021 Jul 21;13:1195-1207. doi: 10.2147/NSS.S318874. PMID: 34321944; PMCID: PMC8310926. [cited 2022 June 13]
45. Tang H, Chen Z, Pang J, Mo Q. [Treatment of insomnia with shujing massage therapy: a randomized controlled trial]. Zhongguo Zhen Jiu. 2015 Aug;35(8):816-8. Chinese. PMID: 26571900. cited 2022 June 13]
46. Timko Olson ER, Hansen MM, Vermeesch A. Mindfulness and Shinrin-Yoku: Potential for Physiological and Psychological Interventions during Uncertain Times. Int J Environ Res Public Health. 2020;17(24):9340. Published 2020 Dec 14. doi:10.3390/ijerph17249340 [cited 2022 June 13]
47. Menon V, Kar SK, Suthar N, Nebhinani N. Vitamin D and Depression: A Critical Appraisal of the Evidence and Future Directions. Indian J Psychol Med. 2020;42(1):11-21. Published 2020 Jan 6. doi:10.4103/IJPSYM.IJPSYM_160_19 [cited 2022 June 13]
48. Kocot, J., Luchowska-Kocot, D., Kiełczykowska, M., Musik, I., & Kurzepa, J. (2017). Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?. Nutrients, 9(7), 659. https://doi.org/10.3390/nu9070659 [cited 2022 June 13]
49. Douaud G, Refsum H, de Jager CA, Jacoby R, Nichols TE, Smith SM, Smith AD. Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9523-8. doi: 10.1073/pnas.1301816110. Epub 2013 May 20. PMID: 23690582; PMCID: PMC3677457. [cited 2022 June 13]
50. LaChance LR, Ramsey D. Antidepressant foods: An evidence-based nutrient profiling system for depression. World J Psychiatry. 2018 Sep 20;8(3):97-104. doi: 10.5498/wjp.v8.i3.97. PMID: 30254980; PMCID: PMC6147775. [cited 2022 June 13]
51. DiGirolamo AM, Ramirez-Zea M. Role of zinc in maternal and child mental health. Am J Clin Nutr. 2009 Mar;89(3):940S-945S. doi: 10.3945/ajcn.2008.26692C. Epub 2009 Jan 28. PMID: 19176735; PMCID: PMC2714398. [cited 2022 June 13]
52. Bailey RL, West KP Jr, Black RE. The epidemiology of global micronutrient deficiencies. Ann Nutr Metab. 2015;66 Suppl 2:22-33. doi: 10.1159/000371618. Epub 2015 Jun 2. PMID: 26045325. [cited 2022 June 13]
53. US Department of Health and Human Services and US Department of Agriculture. 2015-2020 Dietary Guidelines for Americans.8th ed. Office of Disease Prevention and Health Promotion; 2015. cited 2022 June 13]
54. Lopresti AL. The effects of psychological and environmental stress on micronutrient concentrations in the body: a review of the evidence. Adv Nutr. 2020;11(1):103-112. [cited 2022 June 13]
55. Golden TL, Springs S, Kimmel HJ, Gupta S, Tiedemann A, Sandu CC, Magsamen S. The Use of Music in the Treatment and Management of Serious Mental Illness: A Global Scoping Review of the Literature. Front Psychol. 2021 Mar 31;12:649840. doi: 10.3389/fpsyg.2021.649840. PMID: 33868127; PMCID: PMC8044514. [cited 2022 June 13]
56. Takeda F, Noguchi H, Monma T, Tamiya N. How Possibly Do Leisure and Social Activities Impact Mental Health of Middle-Aged Adults in Japan?: An Evidence from a National Longitudinal Survey. PLoS One. 2015;10(10):e0139777. Published 2015 Oct 2. doi:10.1371/journal.pone.0139777 [cited 2022 June 13]
57. Rohan KJ, Meyerhoff J, Ho SY, Evans M, Postolache TT, Vacek PM. Outcomes One and Two Winters Following Cognitive-Behavioral Therapy or Light Therapy for Seasonal Affective Disorder. Am J Psychiatry. 2016 Mar 1;173(3):244-51. doi: 10.1176/appi.ajp.2015.15060773. Epub 2015 Nov 5. PMID: 26539881; PMCID: PMC4939843. [cited 2022 June 13]
58. Hu Z, Oh S, Ha TW, Hong JT, Oh KW. Sleep-Aids Derived from Natural Products. Biomol Ther (Seoul). 2018;26(4):343-349. doi:10.4062/biomolther.2018.099 [cited 2022 June 13]
59. Apaydin EA, Maher AR, Shanman R, et al. A systematic review of St. John’s wort for major depressive disorder. Syst Rev. 2016;5(1):148. Published 2016 Sep 2. doi:10.1186/s13643-016-0325-2 [cited 2022 June 13]
60. Bozzatello P, Rocca P, Mantelli E, Bellino S. Polyunsaturated Fatty Acids: What is Their Role in Treatment of Psychiatric Disorders?. Int J Mol Sci. 2019;20(21):5257. Published 2019 Oct 23. doi:10.3390/ijms20215257 [cited 2022 June 13]
Originally Published Oct 30, 2018 by Lyle Murphy, Founder
Dr. Samuel Lee is a board-certified psychiatrist, specializing in a spiritually-based mental health discipline and integrative approaches. He graduated with an MD at Loma Linda University School of Medicine and did a residency in psychiatry at Cedars-Sinai Medical Center and University of Washington School of Medicine in Seattle. He has also been an inpatient adult psychiatrist at Kaweah Delta Mental Health Hospital and the primary attending geriatric psychiatrist at the Auerbach Inpatient Psychiatric Jewish Home Hospital. In addition, he served as the general adult outpatient psychiatrist at Kaiser Permanente. He is board-certified in psychiatry and neurology and has a B.A. Magna Cum Laude in Religion from Pacific Union College. His specialty is in natural healing techniques that promote the body’s innate ability to heal itself.
Lyle Murphy is the founder of the Alternative to Meds Center, a licensed residential program that helps people overcome dependence on psychiatric medication and addiction issues using holistic and psychotherapeutic methods.