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Cymbalta Alternatives

This entry was posted in Antidepressant and tagged on by .
Medically Reviewed Fact Checked

Last Updated on June 21, 2022 by Carol Gillette

Alternative to Meds Editorial Team
Medically Reviewed by Dr Samuel Lee MD

Alternatives to Cymbalta® are available but generally ignored as first-line treatments. Antidepressant medications can shortcut medical investigations or effective lifestyle interventions. We have been focused on changing that on a daily basis at Alternative to Meds Center for more than 15 years.

There are many possible causes of depression. Below we discuss a number of these, such as impaired hormonal states, deficiency of vitamin D, substandard diet, adrenal fatigue, lack of exercise, failed life aspirations, and others.4 Non-drug-based treatments provide safe and effective alternatives to Cymbalta or other drugs to effectively resolve psychiatric symptoms without the risks of medication side effects.

Does Your Diagnosis
Require Cymbalta?

success getting off cymbalta
Alternative to Meds has been the expert on antidepressant alternatives for over 15 years. In the link following, you can read our published evidence regarding the remarkable successes of our clients. 77% of antidepressant users going through Alternative to Meds treatments are able to stay off of antidepressants long-term and find subjective symptomatic relief not found on the drugs. We understand that during a time of stress or crisis, Cymbalta may be warranted. But these life situations can and do change. Once the crisis has shifted, alternatives to Cymbalta may actually provide higher levels of health and wellness that you can depend on for the rest of your life.

Why Choose Cymbalta Alternatives?

natural cymbalta alternativesA host of Cymbalta alternatives can provide options other than struggling with Cymbalta side effects and ineffectiveness.18 We are aware that many Cymbalta substitutes may very well yield better answers than living the rest of life medicated on antidepressants.

Do you want a loved one or yourself to live life without drugs and return to feeling well? Alternative to Meds Center can custom-design effective Cymbalta tapering alternatives that simplify the process and alleviate medication-associated problems.

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What Is Cymbalta (Duloxetine)?

cymbalta duloxetine SNRICymbalta, AKA duloxetine falls under the classification of serotonin-norepinephrine reuptake inhibitor (SNRI).17 Cymbalta is prescribed to treat depression, generalized anxiety disorder (GAD), chronic musculoskeletal pain (including back pain and arthritis), fibromyalgia, and peripheral diabetic neuropathy pain (hand, feet, arm, or leg nerve pain due to diabetes).20 Depression is the most frequent condition for prescribing Cymbalta.20 However, according to our studies, opting for Cymbalta natural alternatives often provides a superior choice.

Side effects or an insufficient response to treatment are possible with all prescription medications. Antidepressant side effects, intolerability, ineffectiveness, and Cymbalta withdrawal symptoms after developing dependency can all occur as a result of treatment with Cymbalta.34

Other Antidepressants as Alternatives to Cymbalta?

other alternatives to cymbaltaTraditional GPs prescribe the bulk of antidepressants.35 When an individual seeks alternatives to Cymbalta, their prescribing doctor’s first recommendation will likely be other antidepressants.35 There are many problems associated with switching to other drugs as an alternative to Cymbalta, especially for individuals trying to avoid Cymbalta side effects. All antidepressant drugs have side-effect risks, the possibility of being ineffective, and cause physical dependence or withdrawal symptoms upon discontinuation.7

Rather than fall into the trap of multiple medications, or shocking the body by switching from one or multiple drugs, we advise looking carefully at natural alternatives that do not generate harm in the name of help.

Natural Cymbalta Alternatives

Fortunately, there are very effective natural Cymbalta alternatives for depression and related symptoms. Much research demonstrates clearly a number of natural, non-drug-based therapeutics for psychiatric conditions, with some easily accessed examples shown below.

Natural Cymbalta alternatives include:
  • Talk therapy, CBT, DBT — these interventions have been shown in clinical trials to be as or more effective in treating depression, with decreased relapse rate and higher quality of life and longevity scores than that of persons treated with medications.21 
  • Change of diet — Keto-based, Paleo, or Mediterranean-style food choices are examples that can help avoid sugars, and excess refined carbs, and provide a good balance between plant-based and protein-based foods.22
  • Opt for unprocessed foods, avoid chemical preservatives, artificial sweeteners, and neurotoxic food additives and flavor enhancers.44
  • Support a healthy microbiome — the second brain — with prebiotics, probiotics, yogurt, and fermented foods daily.53
  • Remove toxins from the workplace, in-home exposure, pesticides, cleaners, etc.3
  • Detox the body of toxic accumulations through sauna, and other forms of cleansing, found in clinical trials to improve cardio, muscular and immune health, and to provide pain relief, better sleep, relaxation, stress reduction, and improved mood.45
  • Physical exercise* — stimulates blood flow, releases neurotransmitters, and has been found as or more effective, with therapeutic effects that often last longer than medications to treat depressive symptoms in many random controlled trials.41-43
  • Traditional Chinese therapeutics such as meditation, acupuncture, yoga, Tai Chi, and QiGong, have been shown in clinical trials to be effective alternative treatments for depression, anxiety, stress, and other unwanted symptoms including chronic pain.54-56
  • Exposure to sunlight or bright light therapy 5
  • Supplements such as SAMe, St. John’s Wort, 5-HTP, vitamin D, magnesium, saffron, and Omega-3 fatty acids, are some examples. 1,2,46-50
  • Get tested for food allergies, and nutritional and hormonal deficiencies, which have been shown to cause symptoms like those for which antidepressants are prescribed.23,51,52

*Studies such as Craft & Perna’s “Benefits of exercise for the clinically depressed.” have shown promising results regarding the therapeutic benefits of exercise in the treatment of clinical depression.

Is Depression Limited to Low Serotonin?

cymbalta low serotoninPhysicians, in an effort to help their patients, often prescribe an antidepressant prior to any significant investigative efforts into why the person is actually depressed.

The low-serotonin theory has been in the spotlight for 3 decades now, sparking much discussion about whether or not serotonin deficiency is the prime factor in clinical depression.38-40 But the answers may be a bit more complex and are still being explored by researchers. Pharmaceutical companies authored this rather incompletely explored theory and through clever wordsmithing, and emotionally impacting visual advertisements, have made SSRI and SNRI drugs such as Cymbalta some of the best-sellers on the market.27 Low serotonin was repackaged in the 80s by the pharmaceutical industry as a “chemical imbalance.” The chemical imbalance theory as a definitive cause of mental illness has now been largely debunked, yet it has a carry-over effect in the thought paradigms of many consumers, who are just looking for relief. Despite the lack of conclusive evidence for the chemical imbalance theory, even if someone were serotonin-deficient,29 it would be unlikely that every depressed person shares the same profile. And even if the individual was not deficient in serotonin prior to taking an antidepressant, the medication itself has been shown to cause a serotonin deficiency to develop after long-term use of serotonergic medications.28 Serotonin-norepinephrine reuptake inhibitors (SNRIs) such as Cymbalta don’t produce serotonin or norepinephrine, they are thought to instead stop the reuptake, in order to increase the availability of serotonin and norepinephrine levels. And voila, you have happiness in a pill, or at least that is the message from the drugmakers.26

Natural hormones and neurotransmitters such as serotonin and norepinephrine are meant for reuptake as they circulate through the body in order for the nerve cell to reuse them. It is a process of conservation. Serotonin plays many roles in the body, both in and outside of the brain and CNS.36 When a drug blocks serotonin from reuptake, enzymes can eventually cause degradation into unusable metabolites, resulting in little to no serotonin left.30

For comparison, this is similar to how one could say that cocaine combats depression — but only for a short time. Cocaine uses up all available dopamine rather than creating more of it.15 Dopamine functions as our reward and pleasure neurochemical.31 When an individual consumes cocaine, the immediate dopamine purge makes everything seems rewarding. However, after all the dopamine is spent and downregulation has occurred,33 this leaves nothing to hold reward or value to the individual.

The mechanics are similar to SSRI and SNRI drugs, but antidepressants such as Cymbalta target serotonin (in the main) and norepinephrine to a lesser extent, and largely ignore other receptors. Serotonin is an inhibitory neurotransmitter that performs thousands of functions within and outside of the CNS.36 One function of serotonin is to inhibit stimulus from the environment and decrease compulsive thinking and behaviors.36 Serotonin also functions to create the sleep neurohormone melatonin.37 Serotonin regulates and affects literally thousands of functions in the body, from heart health to blood clotting to the endocrine system, reproduction, body temperature, insulin, mood, metabolism, bone mineral density, and uncountable other tasks. Too much serotonin in the system becomes toxic, as can occur with medications that block it and cause serotonin to build up, rather than be processed normally. No antidepressant synthesizes (creates) more serotonin — however, the naturally occurring amino acid tryptophan does play a role in the creation of serotonin.16 Downregulation (reduction of the number or density of active receptors, lessened sensitivity) is also linked to antidepressants and other drugs, most observably where their effectiveness can be seen to wane over time.33

Norepinephrine is also a target in SNRI medications. Norepinephrine is another word for adrenaline, an excitatory neurochemical that is involved in many body functions including heart rate, muscle contraction, and the fight-or-flight response associated with adrenaline. Cymbalta (duloxetine) blocks the reuptake of these molecules, along the pathways of the central nervous system, which creates similar liabilities in the way antidepressants exhaust the availability of serotonin or other targeted neurochemicals over the long term. While there are limited clinical trials on long-term Cymbalta, a number of Korean researchers have reported their concerns about DILI, which means drug-induced liver injury, that has been clinically observed in connection with long-term use of Cymbalta.57,58

Common Causes of Depression and Alternative to Meds Center’s Holistic Alternatives to Cymbalta

holistic cymbalta protocolsAlternative to Meds Center’s medical team oversees individuals as they reduce dependence on psychiatric medications and find natural alternatives without the negative impacts. We discover the medical reasons that may contribute to a person’s depression or anxiety. Our program employs lab testing to determine underlying factors that could have been overlooked. We provide natural substances to create neurochemistry stabilization. Cleansing is done to remove environmentally accumulated toxins.3 The center’s careful withdrawal techniques, plus targeted nutritional therapies and orthomolecular diet guidelines, IV treatment, massage and other spa services, peer support, exercise, acupunctureyoga, Qigong, equine therapy, counseling, nebulized glutathione treatments, and many other natural Cymbalta alternatives serve to combat depression without relying on prescription medications.

Success with Alternatives to Cymbalta

successful cymbalta alternativesWe find success each and every day at Alternative to Meds Center. In celebration of our participants’ successful achievements, we have weekly graduations. Each event includes friends and family of the participant and fellow residents. A number of unbelievable stories have been heard at these events, some of them recount decades spent in prolonged suffering, spoken now with extraordinary levity and hope.

This is very inspiring when we get to see this, knowing they have all the tools to preserve a healthy way of life and continue to be a beacon for other people. We invite you to give us a call to learn more about the kind of natural Cymbalta alternatives help that is available in-patient style, for yourself or a loved one.


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45. Hussain J, Cohen M. Clinical Effects of Regular Dry Sauna Bathing: A Systematic Review. Evid Based Complement Alternat Med. 2018;2018:1857413. Published 2018 Apr 24. doi:10.1155/2018/1857413 [cited 2022 June 13]

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57. Brittanica [online] Norepinephrine [cited 2022 June 13]

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Originally Published Oct 30, 2018 by Lyle Murphy


This content has been reviewed and approved by a licensed physician.

Dr. Samuel Lee

Dr. Samuel Lee is a board-certified psychiatrist, specializing in a spiritually-based mental health discipline and integrative approaches. He graduated with an MD at Loma Linda University School of Medicine and did a residency in psychiatry at Cedars-Sinai Medical Center and University of Washington School of Medicine in Seattle. He has also been an inpatient adult psychiatrist at Kaweah Delta Mental Health Hospital and the primary attending geriatric psychiatrist at the Auerbach Inpatient Psychiatric Jewish Home Hospital. In addition, he served as the general adult outpatient psychiatrist at Kaiser Permanente.  He is board-certified in psychiatry and neurology and has a B.A. Magna Cum Laude in Religion from Pacific Union College. His specialty is in natural healing techniques that promote the body’s innate ability to heal itself.

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