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Trileptal Withdrawal Symptoms, Side-Effects, Treatment Help

Trileptal Withdrawal Symptoms, Side-Effects, Treatment Help

This entry was posted in Signs & Symptoms on by .

Last Updated on March 9, 2021 by Carol Gillette

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Alternative to Meds Editorial Team
Written by Diane Ridaeus Published on: Sep 19, 2018
Medically Reviewed by Dr Samuel Lee MD

Trileptal withdrawal can inflict intolerable adverse effects, especially without the help of compassionate and effective protocols to protect your health.

A person taking the anticonvulsive medication Trileptal may experience impaired cognitive functions. Consequences such as forgetting to take a dose, or other lapses, suggest that one would be wise to enlist help should one decide to quit taking the drug. We have helped thousands of clients at Alternative to Meds Center to complete medication withdrawal successfully in a comfortable and relaxed setting.

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Alternative to Meds Center has been focused on antidepressant withdrawal, offering programs allowing a person to safely wean off Trileptal for over 15 years. Our published evidence clearly demonstrates the success of our clients. Many ATMC staff have personal experience with coming off Trileptal and similar drugs. This is why we feel genuinely called to assist others. We have found that each person needs an individualized application of methods of support. Testing reveals some people are neurotoxic, assessments help demonstrate that others need lifestyle changes, and dietary and supplementation programs. Others may have genetic factors that act as contributors, and there are those whose medical conditions can be identified and assisted.
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What Is Trileptal Used For?

While the drug was first marketed to treat partial seizures, other uses have become more prevalent. Doctors may prescribe Trileptal to children as young as two years of age, though pregnant women are advised not to breastfeed as the drug will pass to the infant directly. Birth defects have not been established according to the National Institute of Health, but have not been ruled out either.1

Although Trileptal or the generic oxcarbazepine was initially used for treating partial seizures in epileptic patients, a number of “off-label” uses have been found for the drug including pain management and bipolar conditions.2

Severe Adverse Effects that May Require Trileptal Withdrawal

Due to some extreme side effects of Trileptal, it may become necessary to stop taking it, for example:

  • Trileptal significantly increased the risk of suicidal ideation and behavior during clinical trials.3
  • Trileptal showed a nearly 2X rate of impaired cognitive and motor functions over placebo, making it risky to drive or operate machinery.
  • A condition known as “DRESS,” (Drug Reaction with Eosinophilia and Systemic Symptoms) can cause fatal or life-threatening reactions including fever, rash, enlarged lymph nodes, facial swelling, liver dysfunction, kidney inflammation, blood abnormalities, inflamed heart muscle or other tissues, etc.
  • Increased risk of Stevens-Johnson syndrome, a potentially life-threatening condition
  • Eosinophilia (abnormally high white blood cell count)
  • Leukopenia (deficiency in white blood cells).

Despite the above adverse effects connected with taking Trileptal, there are no FDA black box warnings on the drug packaging. Never abruptly stop taking Trileptal and don’t try to do it on your own. Always seek help and support before attempting to withdraw from Trileptal. If severe adverse effects present, such as the above list, a physician or clinician may need to reduce the drug more rapidly or even entirely, due to the risk of fatality that continuing the medication might present. Abruptly stopping Trileptal could only be done safely in a clinical/medical setting where emergency treatment is on hand to help ensure the person survives.

Natural Alternatives to Antidepressant Drugs

Because the drug is known to induce relaxation and emotional dulling, it is possible that a doctor prescribed it as an antidepressant. For the treatment of depression, alternative therapies are becoming more popular due to the undesirable risks and adverse consequences of potent medications such as Trileptal.

We provide educational steps in our treatment plans to acquaint our clients with alternative treatments for depression, which do not include drug therapy. One such example of alternative treatments for depression that has received much careful study is checking for and correcting Vitamin D3 deficiency. There are many of these types of drug-free therapies that you can learn about in our educational component.4,5

Find Out More About the Alternative to Meds Center

natural trileptal treatmentWhether your doctor prescribed Trileptal for the treatment of partial seizures, depression, bipolar, pain management, or for any other reason, Alternative to Meds Center is here to help our clients find the best path to their physical and mental health goals. We specialize in holistic, medically supervised protocols and treatment for drug withdrawal. Often, doctors will prescribe multiple drugs along with Trileptal. Tapering from more than one medication can seem like a daunting task, nearly impossible to untangle. We can help.

Call us today for more information on our protocols, treatment timelines, insurance coverage, and any other questions you may have. Our center may be able to offer you the treatment you have been seeking. You are not alone. Find out how Alternative to Meds Center program can help you or a loved one to successfully overcome the challenges of Trileptal withdrawal.


1. Moigaard-Nielsen D, Newer-generation antiepileptic drugs and the risk of major birth defects, JAMA 2011 May [INTERNET] [cited 2020 Mar 9]

2. Oxcarbazepine Information Letter NAMI Jan 2016 [INTERNET] [cited 2020 Mar 9]

3. FDA Information Sheet Trileptal/oxcarbazepine [INTERNET] [cited 2020 Mar 9]

4. Penckofer S, Kouba J, Byrne M, Estwing Ferrans C, “Vitamin D and Depression – Where is all the Sunshine?” Issues Ment Health Nurs June 2010 [INTERNET] [cited 2020 Mar 9]

5. Scaccia A, Legg T J, “Is a Vitamin D Deficiency Causing Your Depression?” Healthline [Internet] 2017 Mar 21 [cited 2020 Aug 17]



This content has been reviewed and approved by a licensed physician.

Dr. Samuel Lee

Dr. Samuel Lee is a board-certified psychiatrist, specializing in a spiritually-based mental health discipline and integrative approaches. He graduated with an MD at Loma Linda University School of Medicine and did a residency in psychiatry at Cedars-Sinai Medical Center and University of Washington School of Medicine in Seattle. He has also been an inpatient adult psychiatrist at Kaweah Delta Mental Health Hospital and the primary attending geriatric psychiatrist at the Auerbach Inpatient Psychiatric Jewish Home Hospital. In addition, he served as the general adult outpatient psychiatrist at Kaiser Permanente.  He is board-certified in psychiatry and neurology and has a B.A. Magna Cum Laude in Religion from Pacific Union College. His specialty is in natural healing techniques that promote the body’s innate ability to heal itself.

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