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Remeron Withdrawal, Side Effects, Addiction, Treatment

This entry was posted in Antidepressant on by .

Last Updated on March 2, 2021 by Carol Gillette

Medical Review Icon

Alternative to Meds Editorial Team
Written by Diane Ridaeus Published Sep 13, 2018
Medically Reviewed by Dr John Motl MD

Physicians are not trained to do a proper Remeron withdrawal, and so the side effects and other complications are often allowed to continue far too long in their patients.

While it might have been prescribed to help with sleep, or lift depression, relief is at best temporary, leaving patients suffering and many times in a worsened state.

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It is very common for us to hear “No one is like me.” And they are correct. Each person is biochemically and spiritually unique and needs to be treated as such. We are not a drug-based treatment model. We use environmental medicine and focus specifically on medication withdrawal and holistic treatment of symptoms. This video shows a woman who was broken, even in her spirit, and barely able to walk. She was imagining her life was over. She successfully completed a benzo and antidepressant withdrawal at ATMC and regained her ability to walk and also got her professional career back!
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Safe Remeron Withdrawal is Possible

Remeron withdrawal can be safely navigated with proper preparation, education, and support along the way. Remeron (mirtazapine) is a tetracyclic atypical antidepressant medication used in the treatment of depression and other off-label uses in adults 18 and older.

Remeron is not approved for patients under age 18 due to increased suicidal thoughts, as stated on the package’s Black Box warning. The patent on Remeron (mirtazapine) expired in 2004. Since then, many other brand name versions have been developed and marketed including Reflex, Mirtin, Tetrazic, Zestat, Zispin, Pharmataz, Miro, Ramure, Calixa, and dozens of others. Remeron side effects for this antidepressant are similar to many other antidepressant medications and may present as mild, moderate, severe, and potentially life-threatening. These reactions may lead to a decision to stop taking Remeron. Seek adequate guidance about how to get off Remeron safely before commencing the task.

Remeron Withdrawal Symptoms

Remeron withdrawal effects during cessation should be observed carefully, even when stopping Remeron slowly, as these include some potentially life-threatening events.

Remeron withdrawal symptoms include:

  • Mania
  • Suicidal thinking*
  • Thoughts of harming self, negative self-talk
  • Tremors, shaking
  • Disturbed sleep, nightmares
  • Hypomania (a less severe form of mania-like symptoms)
  • Nausea, vomiting
  • Decrease in appetite
  • Increased tiredness, fatigue
  • Flu-like symptoms
  • Mood swings, crying spells
  • Confusion
  • Depression
  • Depersonalization
  • Allergies
  • Irritability
  • Sweating
  • Headache
  • Prickling skin sensations
  • Dizziness

*See the FDA black box warning for more information on the increased risk of suicide in specific age groups with Remeron (mirtazapine).

Discontinuing/Quitting Remeron (mirtazapine)

Talk to a trusted healthcare practitioner who can help you devise and implement a structured, safe plan for Remeron withdrawal over a period of time. Never attempt a “cold turkey” approach to coming off antidepressants of any type. Stopping Remeron can be done most safely with guidance and attentive medical support.

Staying hydrated, getting enough rest, eating well are some of the things you can do to help to stop taking Remeron gently, without getting extremely sick.

Gradual Remeron Withdrawal Recommended

Remeron withdrawal can also cause adverse effects and must be done gradually. The FDA and other regulatory bodies stipulate that this drug should never be stopped abruptly. A slow Remeron taper is recommended as this allows time for the body to adjust in a more gentle fashion.7

We will cover some frequently asked questions about Remeron below. Please consult your primary caregiver for specific guidance or if you have concerns about taking Remeron or are considering Remeron withdrawal. Be aware of drug reactions that seem unusual or make you feel uncomfortable. To assist you in gathering information, we can also provide more information on request concerning stopping prescription medication safely. If the decision is made to stop taking mirtazapine, or any prescription drug, it should always be done with close medical oversight and competent guidance.

Remeron Withdrawal

At ATMC I was always supported. The staff was great at providing opportunities for me to work towards stability. What helped me here was always keeping a positive outlook and the constant encouragement and reminders to keep faith in myself.



What is Remeron (mirtazapine) Used For?

Remeron (mirtazapine) was approved primarily for the treatment of MDD or major depressive disorder. MDD symptoms are described in the DSM V and include certain diagnostic criteria.

  1. Symptoms should not be included that are clearly attributable to another medical or pathological condition.
  2. The physiological effects of a substance arenot attributable to the depressive episode.

As stated, before diagnosing a person with MDD, at least the 2 above elements (along with other diagnostic criteria) must be verified.1


Antidepressants are often used in conjunction with multiple medications and electroshock therapy to treat psychiatrically diagnosed conditions. The DSM V has come under considerable scrutiny by some in the medical field.2 It should be noted that the DSM V diagnostic criteria changes apply to adults as well as to adolescents and children.6

It would follow that adequate testing, and investigation would have to be done to rule out these potential root causes for a depressed condition before attempting to medicate the patient. A plethora of alternative therapies exist, which are safer and comfortably sustainable without the negatives of drug-based therapy.

Such investigations would have to include at a minimum, testing for nutritional deficiencies, environmental toxins, food or other allergies, the presence of neurotoxic elements like heavy metals, pathologies, drug use, addiction or dependence, and many other potential agents or influences or substances known to be causal agents in depressed states. These are the exact types of protocols that are used in the Alternative to Meds Center Remeron withdrawal treatment programs.

Remeron off-label uses include:

  • PTSD
  • Insomnia3
  • Itching
  • Nausea
  • Tension headache
  • As an appetite stimulant4,5

Remeron (mirtazapine) Alternative Names and Slang

As discussed earlier, there are a substantial number of names for mirtazapine around the world. When mirtazapine is combined with venlafaxine it is sometimes called “California Rocket Fuel,” indicating recreational use.

Remeron Side Effects

There can be a wide range of side effects experienced while taking mirtazapine or Remeron.

Common Remeron Side Effects can include:

  • Sedation (can be severe)
  • Depression
  • Worsened depression
  • Suicidal thoughts or behavior –FDA recommends monitoring the patient for emerging suicidal thoughts or behavior 7
  • Tremor
  • Convulsions
  • Swelling (tongue, lips, or other parts of the body)
  • Vertigo (spinning sensation, loss of balance, whirling feeling)
  • Flu-like symptoms (sore throat, fever, cough, etc.)
  • Ulcers (in the mouth or other mucous tissues)
  • Abdominal pain
  • Back pain
  • Muscle pain
  • Low blood pressure
  • Vomiting
  • Weakness
  • Stupor (loss of consciousness, appears drunken)
  • Ataxia (loss of full control of body motions)
  • Akathisia (distressed, agitated state of restlessness and compulsive motion caused by antidepressants and other medication)
  • Restless legs
  • Dementia
  • Loss of taste or perversion of sense of taste
  • Gum hemorrhage
  • Intestinal bleeding
  • Intestinal obstruction
  • Dyspepsia (indigestion)
  • Hot flashes
  • Decreased libido
  • Skin rash
  • Short of breath
  • Mental changes (confusion, anger, dispassionate, anxiety, irritability, etc.)
  • Edgy
  • Agitation
  • Twitching
  • Unusual dreams
  • Interrupted sleep
  • Drowsy, tiredness
  • Dizziness
  • Elevated mood
  • Euphoria
  • Anhedonia (inability to feel pleasure, lack of usual or natural pleasurable emotional response)
  • Increased appetite
  • Cravings (carbohydrates or junk food)
  • Weight gain
  • Constipation
  • Xerostomia (dry mouth)
  • Menstrual pain
  • Changes in vision
  • Enlarged salivary glands
  • Excess salivation
  • Drooling
  • Gastritis (inflammation of the stomach lining)
  • Pancreatitis (inflammation of the pancreas)
  • Mania (presents as exaggerated self-esteem, decreased need for sleep, racing thoughts, impulsive behavior without regard for consequences, i.e., excessive shopping sprees, a flight of expansive or delusional thoughts, etc.)

Remeron (Mirtazapine) FAQs

Remeron has been around since the late 1990s. Over time, a fairly substantial body of information has been able to accumulate on the drug. Here are some of the topics and questions that are often searched for.

Is Mirtazapine a Narcotic?

Mirtazapine is a tetracyclic atypical antidepressant but is not conventionally defined as a narcotic. It can have some narcotic effects; a narcotic is defined as a substance that affects mood or behavior. There is often a connotation of illegality when the word narcotic is used, which legal overtones do not typically apply to mirtazapine.

How Does Mirtazapine Work?

It is not known how mirtazapine works exactly or how it treats depression in the brain. Since it has effects on the release and receptivity of both noradrenaline and serotonin as defined by the manufacturer’s pharmacodynamics profile, its overall effects may demonstrate as similar to an SNRI even though the mechanisms of action does not involve neurotransmitter reuptake. Remeron is also believed to have an antihistaminic effect that is thought to be associated with its observed capacity to stimulate.

Based upon biochemical individuality, this drug can be either stimulating or sedating depending on the individual’s personal genetics, age, and dosing level. It has been demonstrated that Remeron tends to be sedating at lower doses and stimulating at higher doses. This aspect alone can result in wildly different responses for the user.7,8 Antidepressants are generally thought to influence the relay of certain chemicals, hormones, neurotransmitters, in the central nervous system including the brain. In general, psychoactive drugs mimic, suppress, stimulate, or cause these natural chemicals to accumulate, or cease to accumulate, leading to sometimes unpredictable results.

No drug creates natural hormones or transmitters; only a healthy, properly nourished body can produce the required substances to support and regulate the systems of the body. During Remeron withdrawal treatment, nutritional support can make a great deal of difference and can ease the process.

Is Mirtazapine/Remeron an Antipsychotic?

No; mirtazapine/Remeron is an antidepressant, of the atypical tetracyclic class referring to the four atomic rings in its structure. It is often used in conjunction with antipsychotic medication. However, caution would be wisely employed here. In certain individuals, Remeron can be stimulating. Additionally, there is the theory regarding what is termed low-histamine psychosis as described most loquaciously by Carl C. Pfeiffer, Ph.D., M.D., and Scott LaMola, B.S. in their published article entitled “Zinc and Manganese in the Schizophrenias.” 9 Remeron’s potential of acting to block histamine 1 receptors may be worth discussing with your doctor when considering antipsychotics in combination with Remeron.

If one wishes to circumvent such complications, it may be beneficial to consider mirtazapine alternative treatments before starting a prescription. Considering an alternative mirtazapine treatment might be a way to avoid the need for a careful mirtazapine taper in the future.

Is Mirtazapine/Remeron like Xanax (Benzodiazepine)?

There are some similarities between Remeron and Xanax. They are both used in the treatment of depression, anxiety, and sleep disorders. However, while Xanax is a benzodiazepine drug, Remeron is not. They have different molecular/atomic structures and affect, influence, or alter the neurochemistry in different ways. Benzodiazepine drugs are thought to primarily affect GABA transmitters, and antidepressants are thought to be serotonergic, dopaminergic, and influence other factors, such as norepinephrine. The more common effects of Remeron typically surround sedation, which lends itself to being interpreted as having a benzo-like effect even though chemically it is highly different. Remeron is often used in combination with Xanax or other benzodiazepines. As stated previously, Remeron can also have a stimulating effect in a significant portion of the population treated with Remeron and this should be considered in persons considering its use, or who are experiencing unintended excitability or anxiety during its use.

Is Mirtazapine/Remeron a Controlled Substance?

Depending on the country, there may be different legal restrictions in place concerning Remeron/mirtazapine. Always check before traveling outside the US if you have concerns about traveling with a prescription drug of any kind.

In the USA, mirtazapine or Remeron is not considered by the FDA as a controlled substance. According to the FDA, the drug has not been adequately studied either in animals or humans to determine the potential for Remeron addiction, tolerance, physical dependence or abuse.10

Treatment for Remeron Addiction and Abuse

At Alternative to Meds Center, we can help a person struggling with mirtazapine dependence or mirtazapine side effects. Often, mirtazapine side effects can become intolerable and this can lead to the decision to stop taking mirtazapine. This is not at all uncommon regarding Remeron side effects.

In some cases, the person’s original symptoms were not helped by the medication, so while these are still present, there is the additional burden of Remeron withdrawal symptoms. Mirtazapine withdrawal can be difficult and could be better managed by inpatient care in a facility equipped to provide withdrawal help, as well as alleviate the original symptoms of distress.

Our protocols at Alternative to Meds Center are time-tested over more than a decade. Each client’s program is individually designed and carefully monitored throughout the mirtazapine withdrawal process to ensure the maximum safety and comfort of the client. If a client has not yet begun taking a medication, there are Remeron alternative treatments that could be considered.

Alternative to Meds Center offers withdrawal help protocols that the most recent DSA revisions have begun to include in their diagnostic criteria. Best practices as delineated therein, now require the elimination of possible physical, pathological, or environmentally linked or causative factors before turning to a prescription drug. This is a sound protocol, but, we have observed, it has not consistently or widely used in general medical or psychiatric practice. We are happy to see these protocols which have been in use at Alternative to Meds Center for well over 12 years, now becoming more mainstream.

Many people have been prescribed antidepressants whose depression, insomnia, or anxiety could have possibly been treated without drugs, had the investigative work been done prior to choosing prescription drugs as the first-line treatment.

Nonetheless, the wheels of progress sometimes turn slowly. Our clinical experience informs us that a significant number, perhaps even a majority, may be suffering from an unnecessary over-prescription of medication that followed a substandard or completely absent investigation of root causes for their symptoms.

Oddly enough, many persons who had an addiction problem to street drugs are given Remeron by a drug treatment program, oftentimes rather indiscriminately. We have seen many patients that struggle from reported mirtazapine dependence or Remeron addiction following such treatment decisions.

We truly feel that reservation of a psychiatric diagnosis for drug addicts should be an operating guideline, at least until the person has had a period of time abstaining from their drug of choice and implementing a healthy diet and behavioral modalities and other helpful remedies. Stopping mirtazapine or Remeron safely would be an important segment of that process and should be done gently and safely.

You are invited to contact us at Alternative to Meds Center to examine more closely how we provide a safe mirtazapine taper program, in our comfortable, relaxed, and beautiful facility, under the supervision of medical staff and highly trained practitioners. Using an integrative approach, more comprehensive investigative steps are taken so we can show each client diversified points that need correcting either psychodynamically, nutritionally or that may respond to neurotoxic body burden removal, and other important clinically relevant and science-based tools. There is much more information Alternative to Meds Center can provide to you on request concerning Remeron withdrawal.

1. Tolentino J, Schmidt S DSM 5 Criteria and Depression Severity: Implications for Clinical Practice. Front Psychiatry [INTERNET] 2018 Oct [cited 2020 Mar 9]

2. Frances Allen, “DSM-5: How Reliable is Reliable Enough?” Psychology Today [INTERNET] 2012 Jan 18 [2020 Jun 29]

3. Karsten J, Hagenauw LA, Kamphuis J, Lancel M Low doses of mirtazapine or quetiapine for transient insomnia, a randomised, double-blind, cross-over, placebo-controlled trial. J. Psychopharmacol [INTERNET] 2017 Mar [cited 2020 Mar 9]

4. Tajti J, Almas J Effects of mirtazapine in patients with chronic tension-type headache [Literature Review]. PubMed, Neuropsychopharmacol Hung [INTERNET] 2011 Jun [cited 2020 Mar 9]

5. Ringeisen H, Casanueva C, Stambaugh L, Bose J, Hedden S DSM-5 Changes: Implications for Child Serious Emotional Disturbance. Center for Behavioral Health Statistics and Quality.(2016). 2014 National Survey on Drug Use and Health: (unpublished internaldocumentation). Substance Abuse and Mental Health ServicesAdministration, Rockville, MD. [INTERNET] [cited 2020 Mar 9]

6. Mirtazapine (Remeron) Information Sheet. NAMI [INTERNET] [cited 2020 Mar 9]

7. Leonard S, Karlamangla A Dose-dependent Sedating and Stimulating Effects of Mirtazapine. UCLA Healthcare [INTERNET] Vol. 19 2015 [cited 2020 Mar 9]

8. Abdulkader A, Voronovich Z, Carley J  A Review of Therapeutic Uses of Mirtazapine in Psychiatric and Medical Conditions. PMCID [INTERNET] 2013 Oct [cited 2020 Mar 9]

9. Pfeiffer C, LaMola S Zinc and Manganese in the Schizophrenias. Journal of Orthomolecular Medicine [INTERNET] 1st quarter 1999 [cited 2020 Mar 9]

10. FDA Label Remeron/mirtazapine [INTERNET] Revised 2016 [cited 2020 Nov 27]

11. Benazzi F. Mirtazapine withdrawal symptoms. Can J Psychiatry. 1998 Jun;43(5):525. PMID: 9653542. [cited 2020 Dec 4]

This content has been reviewed and approved by a licensed physician.

Dr. John Motl, M.D.

Dr. Motl is currently certified by the American Board of Psychiatry and Neurology in Psychiatry, and Board eligible in Neurology and licensed in the state of Arizona.  He holds a Bachelor of Science degree with a major in biology and minors in chemistry and philosophy. He graduated from Creighton University School of Medicine with a Doctor of Medicine.  Dr. Motl has studied Medical Acupuncture at the Colorado School of Traditional Chinese Medicine and at U.C.L.A.

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Remeron Withdrawal, Side Effects, Addiction, Treatment
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Nothing on this Website is intended to be taken as medical advice. The information provided on the website is intended to encourage, not replace, direct patient-health professional relationships. Always consult with your doctor before altering your medications. Adding nutritional supplements may alter the effect of medication. Any medication changes should be done only after proper evaluation and under medical supervision.

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