Oxycodone has an elevated risk for addiction, which means that when you stop taking it, significant withdrawal symptoms occur, often leading to drug cravings and repeated use. This article will discuss some of the most frequently asked questions about oxycodone, why the side effects and withdrawals can be harsh, important information about recovery after addiction to oxycodone, and many other topics.
Oxycodone is a member of the opiate drug class and, as is the case with all opioid drugs, interferes with the way that neurotransmitters perceive and respond to pain.
There are two main neurotransmitters that control pain:
Endorphins and enkephalins are hormones, or peptides, that the body creates which have a powerful ability to kill pain. These natural chemicals can block pain so thoroughly, that should a severe injury occur, the victim may be absent of pain given that adequate levels of these are present during such trauma. These hormones also produce something of a “high”, which can be moderately addictive. For instance, a person may become chemically addicted to the rush of strenuous exercise, or the rush of endorphins that can accompany compulsive self-harm, such as “cutting”.⁴
Opiate drugs mimic these chemicals. Oxycodone was manufactured to act as a synthetic analogue to natural endorphins, in other words, to take the place of naturally produced chemicals.²
When the body is exposed to synthetic analogues, such as oxycodone or other synthetic drugs, the body responds by stopping the production of the natural chemicals. This creates a pain control deficit – a major factor in the extremely painful withdrawal symptoms that occur when quitting a drug like Oxycodone.
Oxycodone is used to control pain ranging from moderate to severe. Many compound drugs contain oxycodone, sometimes compounded with other analgesics, such as Vicoden and Percocet. Oxycontin is an extended release form of oxycodone. Uses for these various medications have expanded to include certain “off-label” uses, such as Fibromyalgia, and treating mental disorders such as depression and anxiety.⁵
Veterans returning from active duty are often high-risk for TBI (traumatic brain injury), chronic pain, and PTSD (post traumatic stress disorder). Despite clinical guidelines advising to the contrary, a study published by NIMH showed that veterans with chronic pain, TBI and PTSD were at a significantly higher risk of being prescribed opioids. ⁶
Common with PTSD, patients will have been subjected to a threat, usually repetitive in nature, which acts as a continuing or repeating danger to survival. This constant threat strains the levels of endorphins and can cause a depletion of them. This is the engagement of a natural survival mechanism to increase the ability to perceive threats in the environment. This endorphin depletion may explain some of the chronic pain issues that often accompany PTSD, and also supports the caution that opioid treatment for this disorder may in fact worsen the condition, as stated by the aforementioned National Institute of Mental Health report.
Oxycodone and drugs containing oxycodone have developed a significant street presence due to their addictive, euphoric effects. Some of the street or slang names include:
Oxycodone produces pain relief and a temporary sense of joy or euphoria. These effects make the drugs high risk for abuse when used recreationally. Side effects include:
Oxycodone withdrawal symptoms can be extremely hard to bear and are best managed in a controlled, medical facility that can provide adequate support throughout the process.
Withdrawal symptoms may begin within hours of the last dose, and can include:
Since synthetic opiates shut down the body’s ability to produce natural endorphins for pain control, quitting oxycodone creates a state of deficiency in these chemicals, which results in not only physical pain but also elevated emotional distress and sensitivity. This state will last until the body can normalize its production of endorphins and enkephalins.
The pain levels, both physical and emotional, can be quite severe and very difficult to bear. It is possible and helpful to employ short-term bridge medications to ease these withdrawals when done in a clinical setting.
Below are some other frequently searched for topics of information relating to oxycodone and how it works in the body and brain.
The Alternative to Meds Center employs protocols which can ease the withdrawals from drugs such as Oxycodone.
Understanding more about opiates and their effect on the emotional aspects of an individual can help in the recovery process, as well as the physical effects.
Regarding the former, a person with adequate levels of natural endorphins could be described as possibly having a significant ability to withstand situations which are emotionally volatile or challenging. In contrast, where natural endorphins are lacking, such a person may almost feel “too emotional”, much like a tuning fork, now open to the uncomfortable onslaught of every emotion in the room.
It is this sort of vulnerable disposition in low-endorphin individuals that can draw them toward long term opiate use, in an attempt to blanket these uncomfortable emotional sensitivities.
Quite apart from emotional pain, physical pain can take a similar grip, especially in a low endorphin person. There are various methods to counter these problems which may benefit a person who wishes to correct such neurochemical deficiencies.
For example, diet is extremely important during the withdrawal and recovery phases of treatment that can significantly alter length of recovery time and intensity of withdrawal symptoms.
If the diet provides the necessary precursors for their corrective effects on neurochemistry, this is one factor that can aid the process considerably.
For instance, the peptides mentioned earlier, such as endorphins, are constructed from amino acids. These can be made amply available through food grade supplements as well as a diet rich in proteins from meats and dense vegetables. With our orthomolecular-based meal-planning, the needed proteins can also be derived from a vegan diet and can be provided in the program.
If desired, in addition to natural endorphin support, where needed, a short-term use of bridge medications such as Suboxone can be used to ensure the withdrawal process is as mild and tolerable as possible.
More information on the treatments at the Alternative to Meds Center for inpatient opiate recovery is given in the opiate alternatives section of this website and we encourage you to become acquainted with all the information provided there. If you would like to receive more information about the program, please contact the Alternative to Meds Center with any further questions about how our treatments and protocols may help you or a loved one become free from opiate dependence.
Dr. Michael Loes is board certified in Internal Medicine , Pain Management and Addiction Medicine. He holds a dual license in Homeopathic and Integrative Medicine. He obtained his medical doctorate at the University of Minnesota, Minneapolis, MN, 1978. Dr Loes performed an externship at the National Institute of Health for Psychopharmacology. Additionally he is a well published author including Arthritis: The Doctor’s Cure, The Aspirin Alternative, The Healing Response and Spirit Driven Health: The Psalmist’s Guide for Recovery. He has been awarded the Minnesota Medical Foundation’s “Excellence in Research” Award.