Oxycodone (oxycodone hydrochloride) is a controlled release opioid analgesic narcotic medication, primarily prescribed for the treatment of moderate to severe pain. Oxycodone is categorized as a Schedule II drug due to its high risk of abuse, which may lead to psychological and/or physical dependence and addiction.
Oxycodone is a medication that has become commonly prescribed for moderate to severe pain. Oxycodone (which was sold under the brand name Oxycontin) has also become a frequently abused drug sold on the street, being used “to get high” rather than to treat a medical condition.
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Alternative to Meds has been the expert on opioid withdrawal for over 17 years. We have published evidence regarding our success. Underlying issues that led to over-reliance on medication can in many cases be addressed in much less toxic ways. We find that frequently there were medical conditions, or that the original factors that contributed to the crisis have since shifted, were diagnosed prematurely or even misdiagnosed. Continuous-release oxycodone is considered highly addictive.
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This article outlines the most common oxycodone withdrawal symptoms and side effects and also provide important information about recovery after addiction to oxycodone, and what options are available in opioid recovery.
Oxycodone Withdrawal Symptoms
Oxycodone withdrawal symptoms can be extremely harsh and are best managed in a setting or facility that can provide adequate support throughout the process. To avoid the risk of dehydration due to loss of bodily fluids, it is recommended to drink 2 to 3 liters of water per day during Oxycodone withdrawal.9
Withdrawal symptoms may begin within hours of the last dose, and can include:
Elevated heart rate
Suicidal thoughts
Depression (can be extreme, and lingering)
Diarrhea
Nausea, vomiting (high risk for dehydration)
Insomnia, unusual dreams, interrupted sleep
Mood swings, irritability
Anxiety
Restlessness, restless leg syndrome
Agitation
Trouble remembering or focusing
Excessive sweating
Hot flashes, chills, goosebumps
Muscle twitches
Headache
Painful muscles and cramping
Runny nose
Watering eyes
Hoarseness
High blood pressure
Excessive yawning
Rebound pain, elevated sensitivity to pain
Neurotransmitters, Pain, and Opioids
Oxycodone is a member of the opiate drug class and, as is the case with all opioid drugs, interferes with the way that neurotransmitters respond to pain.
There are two main agents that control pain as a natural function of a healthy body:
Endorphins
Enkephalins1
Endorphins and enkephalins are natural chemicals that the body creates and releases into the bloodstream that have a powerful ability to kill the sensation of pain. These natural chemicals can block pain so thoroughly, that should a severe injury occur, the victim may be absent of pain for a period of time. Natural hormones can produce a sense of euphoria, which can be moderately addictive. For instance, a person may become chemically addicted to the rush of strenuous exercise, or the rush of endorphins that can accompany compulsive behaviors, such as “cutting.” and gambling.4
The exact mechanisms of how opiates provide pain relief are not completely understood, but the depression on respiratory effects have been traced to suppression of activity in the brain stem.10
When the body is exposed to synthetic analogs, such as oxycodone, the body responds by stopping the production of these natural chemicals. This creates a pain control deficit — a major factor in the extremely painful withdrawal symptoms that occur when quitting a drug like oxycodone.
What Is Oxycodone Used For?
Oxycodone is used to control pain ranging from moderate to severe. Many compound drugs contain oxycodone, sometimes compounded with other analgesics, such as Vicodin and Percocet. Oxycontin is an extended-release form of oxycodone. Uses for these various medications have expanded to include certain “off-label” uses, such as Fibromyalgia, and treating mental disorders such as depression and anxiety.5
Veterans returning from active duty are often at high risk for TBI (traumatic brain injury), chronic pain, and PTSD (post-traumatic stress disorder). Despite clinical guidelines advising to the contrary, a study published by NIMH showed that veterans with chronic pain, TBI, and PTSD were at a significantly higher risk of being prescribed opioids.6
Common with PTSD, patients will have been subjected to a threat, usually repetitive in nature, which acts as a continuing or repeating danger to survival. This constant threat strains the levels of endorphins and can cause a depletion of them. This is the engagement of a natural survival mechanism to increase the ability to perceive threats in the environment. This endorphin depletion may explain some of the chronic pain issues that often accompany PTSD, and also supports the caution that opioid treatment for this disorder may in fact worsen the condition, as stated by the aforementioned National Institute of Mental Health report.
Oxycodone Alternative Names and Slang
Oxycodone and drugs containing oxycodone have developed a significant street presence due to their addictive, euphoric effects. Some of the street or slang names include:
Hillbilly heroin
Blues
Kickers
Oxy
OC
Ox
Oxycotton
40s or 80s (referring to the strength in mg)
Killers
Oxycodone Side Effects
Oxycodone produces pain relief and a temporary sense of joy or euphoria. These effects make the drugs high risk for abuse when used as prescribed, or used recreationally. Most persons become addicted to opiates unintentionally.
Oxycodone side effects include:
False or unusual joy or euphoria, mood swings, crying, despondency, irritation
Constipation (can be severe requiring medical intervention)
Increased thirst
Weight loss or weight gain
Sunken eyes or facial features
Miosis (pinpoint pupils)
Tender painful lymph glands (neck, armpit, groin)
Extreme fatigue, drowsiness, tiredness
Discontinuing/Quitting Oxycodone
Since synthetic opiates shut down the body’s ability to produce natural endorphins for pain control, quitting oxycodone reveals a state of deficiency in these chemicals, which results in not only physical pain but also elevated emotional distress and sensitivity. This state will last until the body can normalize its production of endorphins and enkephalins. Alternative to Meds Center’s oxycodone withdrawal program employs orthomolecular medicine as part of the protocols in recovery to assist in neurotransmitter rehabilitation.
Without assistance, the pain levels, both physical and emotional, can be quite severe and very difficult to bear. It is helpful to employ short-term bridge medications and deep tissue cleansing as well as therapeutic massage and other comfort therapies to ease these withdrawals for our clients at the center.
Oxycodone FAQs
Below are some frequently searched topics of information relating to oxycodone addiction, oxycodone withdrawal, and other topics of interest.
Is Oxycodone Synthesized from Opium?
Yes, oxycodone is made in a lab by synthesizing opium from opium poppies. Like all opioids, oxycodone binds to the various opioid receptors found prevalently in the bowels and certain parts of the brain. This binding characteristic is one of the mechanisms of opioid addiction.
Is Oxycodone Synthesized from Opium?
Yes, oxycodone is made in a lab by synthesizing opium from opium poppies. Like all opioids, oxycodone binds to the various opioid receptors found prevalently in the bowels and certain parts of the brain. This binding characteristic is one of the mechanisms of opioid addiction.
Is Oxycodone Safe in Pregnancy?
Apart from studies on sheep, rats, and other animals, few clinical trials have been done involving pregnancy and oxycodone. What is known is that infants born to mothers taking opiates regularly during pregnancy can suffer opiate withdrawals themselves, including difficulty breathing, irritability, and other problems requiring medical intervention.8,13
How Does Oxycodone Work?
Oxycodone provides a synthetic version of certain natural chemicals normally produced in the intestines and brain. The presence of oxycodone signals the body to shut down its production of the pain-dampening natural chemicals such as dopamine, endorphins, and enkephalins. A defense mechanism kicks in to compensate, and the body begins to build new pain receptors. This response is called “up-regulation.”11,12
The body is ready-made with this rugged survival mechanism, which might be compared to enhanced radar, increasing the capability for a heightened response to threats such as incoming pain signals. When the drug is withdrawn, two factors are thought to explain the level of discomfort. First, there is a general deficit of endorphins and dopamine being shut down. And magnification of pain occurs due to the extra pain receptors that have been created. These extra pain receptors will atrophy to normal levels after a period of time, especially with precisely targeted nutritive support, allowing the body’s central nervous system a chance to rebalance itself. Without assistance in a clinical setting, this transition can become unbearably painful.
Treatment for Oxycodone Withdrawal, Abuse, and Addiction
Understanding more about opiates and their effect on the emotional and physical aspects of an individual can help in the recovery process. An educational component is part of the program to increase understanding of how opiates affect the body in specific ways.
If a person has normal and adequate levels of natural endorphins, this provides something of a buffer against emotional upheavals and pain. Without adequate endorphin production, a person may experience too much emotional or physical pain.
It is this sort of vulnerable disposition found in low-endorphin individuals that can draw them toward long-term opiate use, in an attempt to blanket or shut out these uncomfortable sensations.
Quite apart from emotional pain, physical pain can take a similar grip, especially profound in a low endorphin person. There are various methods to counter these problems which may benefit a person who wishes to correct such neurochemical deficiencies.
This is why changing the diet is extremely important during the withdrawal and recovery phases of treatment and can significantly shorten recovery time and de-intensity oxycodone withdrawal symptoms.
The diet can provide the necessary precursors for their corrective effects on neurochemistry. This is one factor that can dramatically aid the recovery process.
Peptides, dopamine, and endorphins are constructed from amino acids. These can be made amply available through food-grade supplements as well as a diet rich in proteins from meats and dense vegetables. With our orthomolecular-based meal planning, the needed proteins can also be derived from a vegan diet and can be provided in the program.
If desired, in addition to natural endorphin support, where needed, short-term use of bridge medications such as Suboxone as well as alternative drug-free treatments can be used to ensure the withdrawal process is as mild and tolerable as possible.
More information on the treatments at Alternative to Meds Center for inpatient opiate recovery is given in the opiate alternatives section of this website and we encourage you to become acquainted with all the information there and on our services overview pages. If you would like to receive more information about our oxycodone withdrawal program, please contact Alternative to Meds Center with any further questions about how our treatments and protocols may help you or a loved one become free from opiate dependence.
7. Shah M, Huecker MR. Opioid Withdrawal. [Updated 2022 May 15]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526012/ [cited 2022 Aug 17]
This content has been reviewed and approved by a licensed physician.
Dr. Michael Loes, M.D.
Dr. Michael Loes is board-certified in Internal Medicine, Pain Management and Addiction Medicine. He holds a dual license in Homeopathic and Integrative Medicine. He obtained his medical doctorate at the University of Minnesota, Minneapolis, MN, 1978. Dr. Loes performed an externship at the National Institute of Health for Psychopharmacology. Additionally, he is a well-published author including Arthritis: The Doctor’s Cure, The Aspirin Alternative, The Healing Response, and Spirit Driven Health: The Psalmist’s Guide for Recovery. He has been awarded the Minnesota Medical Foundation’s “Excellence in Research” Award.
Medical Disclaimer: Nothing on this Website is intended to be taken as medical advice. The information provided on the website is intended to encourage, not replace, direct patient-health professional relationships. Always consult with your doctor before altering your medications. Adding nutritional supplements may alter the effect of medication. Any medication changes should be done only after proper evaluation and under medical supervision.
Fact Checked
Alternative to Meds Editorial Team
Endorphins and enkephalins are natural chemicals that the body creates and releases into the bloodstream that have a powerful ability to kill the sensation of pain. These natural chemicals can block pain so thoroughly, that should a severe injury occur, the victim may be absent of pain for a period of time. Natural hormones can produce a sense of euphoria, which can be moderately addictive. For instance, a person may become chemically addicted to the rush of strenuous exercise, or the rush of endorphins that can accompany compulsive behaviors, such as “cutting.” and gambling.4
Veterans returning from active duty are often at high risk for TBI (traumatic brain injury), chronic pain, and PTSD (post-traumatic stress disorder). Despite clinical guidelines advising to the contrary, a study published by NIMH showed that veterans with chronic pain, TBI, and PTSD were at a significantly higher risk of being prescribed opioids.6
The diet can provide the necessary precursors for their corrective effects on neurochemistry. This is one factor that can dramatically aid the recovery process.
