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Pristiq (desvenlafaxine) Withdrawal Symptoms

FDA WARNING:  Never abruptly stop taking Pristiq©, as rapid or abrupt cessation can be extremely difficult to endure, and sometimes life-threatening. Always seek competent medical assistance for Pristiq withdrawal treatment.5,7-14,17

Pristiq withdrawal symptoms even when reducing the dosage slowly can be extremely hard to tolerate, and therefore need to be closely monitored. Some persons will have an easier time if gradual cessation is done in an inpatient-style program with strong support.

Pristiq withdrawals can include:
  • Suicidality 4,8
  • Hyperarousal, anxiety, agitation 10
  • Dizziness, vertigo, imbalance, lightheadedness 7-9
  • Mania, hypomania 4,12,14
  • Psychosis, visual and audio hallucinations 10
  • Amnesia 11
  • Insomnia, disturbed sleep, vivid dreams, nightmares 7-9
  • Seizures 4
  • Brain zaps, shivers, jolts, “head shock” sensations* 5
  • Weakness, myalgia, headache, chills, and other flu-like symptoms 4,8
  • Mood swings, i.e., crying spells, depression, irritability 4-8
  • Nausea, vomiting 4,6-10
  • Diarrhea, gastrointestinal discomfort, constipation, abdominal pain 10,15
  • Paresthesia, burning or prickling sensations on the skin 8
  • Movement disorder 11,13

*Brain zaps are known to occur when coming off antidepressants, sometimes even when the withdrawal is done slowly. The phenomenon has been associated with lateral eye movements but remains poorly understood. There is no medical explanation beyond the observation that they occur commonly in antidepressant withdrawal.5


The good news is that Pristiq withdrawal can be surprisingly mild using a comprehensive set of holistic protocols and a closely monitored gradual reduction.

Pristiq (desvenlafaxine) is an FDA-approved SNRI drug in extended-release, oral pill form for treating MDD (major depressive disorder) and various off-label uses. Antidepressants are often prescribed off-label without strong evidence of their benefits relative to risks.6

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Discontinuing/Quitting Pristiq (desvenlafaxine)

Because Pristiq (desvenlafaxine) is a timed-release medication, it may be necessary for the prescribing physician to consider cross-tapering or other strategies to overcome this factor. Clinical expertise is essential for these methods of withdrawal to be done correctly, making the process considerably easier for the patient.

Cross-tapering should only be done in an inpatient setting where close monitoring is possible. In this way, one can avoid any risks that can be associated with incorrect dosages, inappropriate drug interactions, or switching medications too abruptly.

Done well, a correct and exact Pristiq taper supplemented with counseling and other social supports can be surprisingly mild.

What Is Pristiq?

Pristiq is a timed-release SNRI antidepressant. The drug interferes with serotonin and norepinephrine receptors in ways that are not completely understood. Researchers report that Pristiq acts aggressively on blocking serotonergic receptors at a 10:1 ratio over norepinephrine receptors.15 Stopping the drug suddenly does not allow the central nervous system to recalibrate, and carries certain risks to health.

Pristiq (desvenlafaxine) was initially approved for sale by the FDA in 2007 for the treatment of depressive disorders. The US patent expired around 2017, but Pfizer submitted a new drug application for a future extended-release version of desvenlafaxine, which will be called “Prism” to replace Pristiq, if the application is approved. 20  Pristiq was withdrawn from sale to European markets for undisclosed reasons. Many generic versions are found today.

Risks Associated with Pristiq

Because of the statistics relating to suicidality which have been well documented during many clinical trials both before and after the drug was first approved, Pristiq is not approved to be prescribed for children, teens, or young adults under the age of 25. However, recent research has found that antidepressant drugs are ALSO associated with increased suicidality in adults, though this is not mentioned on the black box that accompanies all such drugs.4,19

Other risks are associated with Pristiq and other similar SNRI antidepressant drugs. All serotonergic medications should be monitored for rare but potentially lethal reactions such as serotonin syndrome and Stevens-Johnson Syndrome (see below for more detailed information). These potential health hazards are other reasons one might consider a medically monitored Pristiq withdrawal and eventual transition to natural Pristiq alternatives.

A wide range of additional adverse effects have been associated with Pristiq (desvenlafaxine) which you will find listed further down in this article. Not everyone who takes Pristiq suffers extreme adverse reactions. Some will experience years of ongoing suffering, and some people will experience minor reactions or none at all. However, some adverse reactions can be life-threatening and would require the appropriate medical intervention.

Make a Plan to Safely Discontinue Pristiq

make a plan to safely discontinueWhere lingering and troublesome adverse effects outweigh the benefits, a person may want to stop taking Pristiq. But one should try to inform oneself of the best ways of stopping Pristiq. FDA guidelines are confusingly vague and very brief on Pristiq withdrawal. The guideline on the drug insert recommends that one reduce the drug as rapidly as possible, but not so quickly as to cause intolerable withdrawal symptoms.4 It is no wonder that doctors in the main are not well-prepared in helping their patients to come off drugs because unfortunately there is little to no training given in medical school on Pristiq withdrawal help. If you are seeking help with Pristiq withdrawal, seek inpatient care but if this is not possible, try and find a physician who is familiar with the process and who has confidence in their ability to help.

When a person elects to stop taking an SNRI medication, or any medication, it is always wise to seek as much information as possible before beginning the process. We can provide much information on request which may help greatly in planning a safe and relatively comfortable Pristiq withdrawal. We urge you to share the information on this page with your prescriber. More information is given below on how to get off Pristiq with addition information related to Pristiq withdrawal help.

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Pristiq Withdrawal
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At ATMC I was always supported. The staff was great at providing opportunities for me to work toward stability. What helped me here was always keeping a positive outlook and constant encouragement and reminders to keep faith in myself.  ~ Jackie

What Is Pristiq (desvenlafaxine) Used For?

Desvenlafaxine is the generic name for Pristiq, which is FDA approved for the treatment of MDD (major depressive disorder) in adults, aged 25 and older.4

The drug is also prescribed off-label for hot flashes associated with menopause, and for women who experience particularly difficult symptoms relating to the menstrual cycle.

Pristiq is considered to be a “non-hormonal” treatment where an alternative hormone treatment is sought to address vasomotor conditions (relating to the muscles and nerves that regulate dilation and constriction of blood vessels) relating to a woman’s menstrual cycle.

Pristiq (desvenlafaxine) Alternative Names and Slang

Desvenlafaxine is the drug’s generic name. Pristiq is not known to be a popularized street drug but has been found in relatively uncommon pharmaceutical drug diversion cases as with other antidepressants. Sometimes called “poor man’s cocaine,” certain antidepressant prescription drugs are crushed and snorted or injected for a rush similar to other stimulant drugs like cocaine or crack. However, such practices often lead to a trip to the nearest hospital for emergency medical care.

Due to Pristiq’s extended-release structure, it is less subject to abuse than immediate-release antidepressant drugs. Perhaps viewed by some as a deterrent, fillers used in prescription pills may be toxic to the skin when injected, potentially creating very deep abscesses that are prone to infection, especially where neglect and poor hygiene can quickly escalate infection and lead to loss of life if left untreated.

Pristiq is one of many brand names for desvenlafaxine (extended release) including:
  • Ellefore©
  • Khedezla©
  • Defaxin ER©
  • Deslafax©
  • Dvenjoy XR©
  • Zyven OD©
  • Ventab©

Pristiq Side Effects

Severe Pristiq side effects can occur as with any SNRI drug. These may require immediate medical intervention for the safety of the patient. It is important to be aware of these while taking an SNRI.

Adverse side effects can be mild to extremely harsh and will affect different people in different ways.

Pristiq side effects may include:
  • Suicidality 19
  • Mania, hypomania 1,4
  • Seizures 4
  • Cardiac arrest 1
  • Severe muscle tightness 1
  • Hyponatremia (abnormally low level of sodium in the blood) 4
  • Weight gain 15
  • Interstitial lung disease, eosinophilic pneumonia 4
  • Increased depression or other worsening symptoms 1,4
  • Thoughts of self-harm 1
  • Unusual bleeding or bruising 1,4
  • Abnormal menstrual cycle 1
  • Cholesterol and triglyceride elevation 4
  • Elevated blood pressure 18,21
  • Glaucoma, mydriasis, eye pain, blurred vision, swelling, or redness around eyes 1,4,17
  • Renal impairment, frequent urination, difficulty urinating 1,4
  • Teeth grinding 1
  • Headache 1,15,17
  • Tachycardia (rapid heart rate at rest), increased blood pressure 4,15
  • Decreased appetite 17
  • Trouble speaking clearly 1
  • Chills, shivering, cold sweats 1
  • Cognitive impairment, confusion 1
  • Swelling 1
  • Numbness 1
  • Shaking, tremors 1
  • Nausea, vomiting 1,15,17
  • Headache 1,15,17
  • Fatigue, drowsiness 1,17
  • Insomnia, abnormal dreams 1,17
  • Sexual dysfunction 1,15,17
  • Anxiety, agitation, irritability, aggressiveness, restlessness 1
  • Hyperhidrosis (excessive sweating) 1,17
  • Constipation 15,17
  • Xerostomia (dry mouth due to dysfunctional saliva glands) 1
  • Cough 15

Additional Severe Pristiq Side Effects

Some of the most severe adverse reactions from Pristiq to be aware of are:
  • Serotonin Syndrome
  • Stevens-Johnson Syndrome
  • Suicidality
  • DRESS (rashes, hypersensitivity, allergic reactions)

Serotonin Syndrome:  When too much serotonin has been activated in the body this can result in a set of life-threatening symptoms including sudden fever, chills, depressed respiration, coma, unconsciousness, and death.

severe adverse reactions from using pristiqStevens-Johnson Syndrome:  This is a rare but severe hive-like reaction of the skin caused by certain medications such as Pristiq, which also targets moist tissues of the mouth, eyes, throat, airways, anus, etc. First presents with fever and flu-like symptoms, followed by the skin erupting into blisters that darken and peel away leaving raw painful tissue. Dehydration, sepsis, pneumonia, and multiple organ failure associated with this condition can lead to death.

Increased Suicidality:  Pristiq was shown to cause an increased risk of suicide in children, teens, and young adults, especially under the age of 25, and is therefore not approved to be prescribed to this age range. However, trials and statistics also show increased suicidality risk in adult populations.

DRESS (drug induced rashes, hypersensitivity):   DRESS stands for Drug Reaction with Eosinophilia and Systemic Symptoms. Eosinophils are a specific type of white blood cell which supports the immune system.”DRESS” means a severe immune system/allergic reaction that affects the skin and other organs in severe and life-threatening ways. Manifestations include fever, painful rash that spreads and blisters, facial edema, fatigue, body aches, and other symptoms. It is a class of reactions of this type (such as Stevens-Johnson, TEN, and others) and these require immediate medical treatment.1,4,19,22,23

Safe Strategies for Pristiq Withdrawal

Coming off an SNRI must be done precisely and gradually. Pristiq, being a time-release medication requires special consideration in how it is dosed. Work with a trusted medical team or caregiver who can help with either cross-tapering, converting to an equivalent non-timed-release drug, or other strategy.

Prepare for the discontinuation process. Diet, exercise, resolving nutritional deficiencies, adequate sleep, all play significant role in health and are important supports in medication management.

Above all, don’t try it on your own. Seek help and be patient with yourself. Network with peer groups or close friends who most likely will be more than willing to help you through the process. Consider learning relaxation techniques, therapeutic massage, and other healthful activities. And, give yourself the space and time to work through this sometimes challenging task. You can call us for more information on strategies that may be useful for Pristiq withdrawal success.

Pristiq (desvenlafaxine) Withdrawal FAQs

Below are some of the most common questions regarding Pristiq (desvenlafaxine).

Are there Pristiq Alternatives?

Medical research has documented many Pristiq alternatives that are available and used in recovery from prescription drug dependence. These are modalities that involve natural neurotransmitter rejuvenation and other important restorative functions that can help address issues that Pristiq was not able to fix.

Here is some further reading to explore:

• Alternatives to Antidepressant Medications
• Holistic Drug and Toxin Detox

If you have other questions, more information is freely available from Alternative to Meds Center on request if you need further knowledge on these or other topics.

What does Pristiq do to your brain?

pristiq serotonin deficiencyIt is thought that an SNRI drug affects two types of chemicals that act as messengers within the brain and central nervous system. One of these is serotonin, a neurochemical that is responsible for regulating things like mood, sexual function, digestion, memory, and many, many other functions of health. Serotonin is an inhibitory agent that allows us to relax the fight or flight responses so that these activities are possible. The other neurochemical that SNRI drugs affect is norepinephrine, which is a direct precursor to adrenaline, the fight-or-flight response neurotransmitter. Norepinephrine is associated with mental focus and learning, yet too much of it clinically presents as anxiety.

SNRI drugs keep serotonin and norepinephrine suspended in the nerve synapses, instead of allowing them to be reabsorbed into and along the nerve pathway. When these agents accumulate, they act more intensely, sometimes with unpredictable results.

However, these natural chemicals will eventually degrade and become waste products, instead of being reabsorbed and recycled ready to be used again. This may eventually result in a deficiency as Pristiq does not create more serotonin or norepinephrine, only a healthy body can do that. This mechanism explains, at least in part, how drugs develop diminished efficacy over time.2

Is Pristiq Different Than Effexor?

Pristiq and Effexor are similar drugs but are not exactly the same.

Similarities:  Pristiq is a time-release drug, and Effexor XR is also a time-release drug. Both drugs share similar reactions. Both drugs have a black box warning regarding suicide and other risks. Because they are both SNRI drugs they share the mechanism of action on serotonin and norepinephrine, almost identically. Effexor immediate-release is no longer marketed in the US but is available in some other countries. Stopping Pristiq can be difficult, similar to stopping Effexor XR or other prescription drugs.

Like Effexor, Pristiq is not generally viewed as an addictive drug, whereas dependence is seen as a more likely outcome.

Differences:  Pristiq is prescribed for MDD (major depression disorder); Effexor is prescribed for various depression disorders as well as anxiety disorders such as SAD (social anxiety disorder), PD (panic disorder), and anxiety GAD (generalized anxiety disorder). Another difference is that at a lower than 75mg dose, Effexor acts more primarily as an SSRI. Pristiq has no similar dose-response relationship and acts as an SNRI whether taken in 50mg or 100mg doses.3

Does Pristiq Increase Blood Pressure?

Yes. Pristiq (desvenlafaxine) can increase blood pressure. If you already have high blood pressure, you should make sure it is well under control before you start taking a prescription of desvenlafaxine. Symptoms of high blood pressure can be completely non-existent, even though the condition exists. So it is wise to have this checked especially before taking medications that can increase hypertension.18,21

Where symptoms of HBP are noticeable, they can include severe headaches, pounding in the chest, ears, or around the neck, confusion, shortness of breath, fatigue, irregular heartbeat, blood in urine, vision problems, and pain in the chest area. Uncontrolled high blood pressure can lead to serious health risks such as internal tissue damage, stroke, or kidney failure. Seek medical help if you experience high blood pressure symptoms to avoid these health risks.

Treatment for Pristiq Withdrawal, Dependence, and Abuse

When deciding to come off a drug such as Pristiq, one would be well-advised to choose to work with medical professionals who are familiar with methods and procedures which can mitigate withdrawal adverse effects to have the best chance of success with cessation. While Pristiq addictive behaviors (i.e., pleasure-seeking behavior despite negative consequences) are less frequently seen, a dependence develops easily once the drug begins to alter the chemistry of the brain and CNS.

If the Pristiq withdrawal is too fast, there is a high risk of relapse, and lengthening the overall process. If the process is too difficult, even if slowly done, and no other guidance or support of any kind is offered, it can be extremely hard to escape relapse as the symptoms of Pristiq withdrawal can be intolerable. There are many beneficial actions that can ease the discomforts that are commonly experienced when trying to stop taking Pristiq.

However, Pristiq withdrawal can be made much easier to tolerate by choosing inpatient treatment, where constant monitoring is routine, and minute changes to dosage may be helpful within a withdrawal schedule designed to fit the urgent and most pressing needs of an individual.

normalize neurochemistryAlternative to Meds Center uses lab testing to help prepare the body for the withdrawal process. If vitamin or mineral deficiencies are present, these can be corrected through supplementation and a carefully planned diet for maximizing the body’s ability to normalize neurochemistry after prescription drugs have created changes that altered or compromised it.

The presence of neurotoxic materials can have a detrimental effect on the central nervous system. Such symptoms as insomnia, depression, and anxiety are linked to certain toxic substances like heavy metals, pesticides, chemicals in foods, cleaners, and many other sources. These toxic accumulations, however prevalent in our modern lifestyles, can be isolated and gently purged, as a very effective way to prepare for and ease a smooth cessation process.

Alternative to Meds Center can provide much more information on request about our center’s safe methods, holistic therapies, diet, nutrition, removal of toxic burden, and many more helpful techniques that can significantly ease Pristiq withdrawal treatment.

1 (800) 301-3753 for Pristiq Withdrawal Help

1. NAMI authors, “Desvenlafaxine (Pristiq)” National Alliance on Mental Illness [online publication] December 2018 [cited 2026 Mar 19]

2. Zhang, G., Gao, Z., Guan, S. et al. “Upregulation of excitatory neurons and downregulation of inhibitory neurons in barrel cortex are associated with loss of whisker inputs.” Mol Brain6,&2 (2013). https://doi.org/10.1186/1756-6606-6-2 [cited 2026 Mar 19]

3. Guzman F MD “Venlafaxine and Desvenlafaxine: Differences and Similarities” Psychopharmacology Institute, 2019 Jun 27 [cited 2026 Mar 19]

4. FDA drug label Pristiq (desvenlafaxine) 2008 [cited 2026 Mar 19]

5. Papp A, Onton JA. Brain Zaps: An Underappreciated Symptom of Antidepressant Discontinuation. Prim Care Companion CNS Disord. 2018 Dec 20;20(6):18m02311. doi: 10.4088/PCC.18m02311. PMID: 30605268. [cited 2026 Mar 19]

6. Wong J, Motulsky A, Abrahamowicz M, Eguale T, Buckeridge DL, Tamblyn R. Off-label indications for antidepressants in primary care: descriptive study of prescriptions from an indication based electronic prescribing system. BMJ. 2017;356:j603. Published 2017 Feb 21. doi:10.1136/bmj.j603 [cited 2026 Mar 19]

7. Rosenbaum JF, Zajecka J. Clinical management of antidepressant discontinuation. J Clin Psychiatry. 1997;58 Suppl 7:37-40. PMID: 9219493. [cited 2026 Mar 19]

8. Henssler J, Heinz A, Brandt L, Bschor T. Antidepressant Withdrawal and Rebound Phenomena. Dtsch Arztebl Int. 2019;116(20):355-361. doi:10.3238/arztebl.2019.0355 [cited 2026 Mar 19]

9. Gabriel M, Sharma V. Antidepressant discontinuation syndrome. CMAJ. 2017;189(21):E747. doi:10.1503/cmaj.160991 [cited 2026 Mar 19]

10. Berber MJ. FINISH: remembering the discontinuation syndrome. Flu-like symptoms, Insomnia, Nausea, Imbalance, Sensory disturbances, and Hyperarousal (anxiety/agitation). J Clin Psychiatry. 1998 May;59(5):255. PMID: 9632038. [cited 2026 Mar 19]

11. Dilsaver SC, Greden JF. Antidepressant withdrawal phenomena. Biol Psychiatry. 1984 Feb;19(2):237-56. PMID: 6324897. [cited 2026 Mar 19]

12. Dilsaver SC, Kronfol Z, Sackellares JC, Greden JF. Antidepressant withdrawal syndromes: evidence supporting the cholinergic overdrive hypothesis. J Clin Psychopharmacol. 1983 Jun;3(3):157-64. PMID: 6348107. [cited 2026 Mar 19]

13. Wolfe RM. Antidepressant withdrawal reactions. Am Fam Physician. 1997 Aug;56(2):455-62. Erratum in: Am Fam Physician 1998 Feb 15;57(4):646. PMID: 9262526. [cited 2026 Mar 19]

14. Howland RH. Potential adverse effects of discontinuing psychotropic drugs: part 2: antidepressant drugs. J Psychosoc Nurs Ment Health Serv. 2010 Jul;48(7):9-12. doi: 10.3928/02793695-20100527-98. Epub 2010 Jun 22. PMID: 20608581. [cited 2026 Mar 19]

15. Naseeruddin R, Rosani A, Marwaha R. Desvenlafaxine. [Updated 2021 Mar 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK534829/ [cited 2026 Mar 19]

16. Skanland S, Cieslar Pobuda A, “Off-label uses of drugs for depression.” European Journal of Pharmacology Vol 865, 15 December 2019, 172732 as published in Science Direct [cited 2026 Mar 19]

17. Liebowitz MR, Tourian KA. Efficacy, safety, and tolerability of Desvenlafaxine 50 mg/d for the treatment of major depressive disorder:a systematic review of clinical trials. Prim Care Companion J Clin Psychiatry. 2010;12(3):PCC.09r00845. doi:10.4088/PCC.09r00845blu [cited 2026 Mar 19]

18. Thase ME, Fayyad R, Cheng RF, Guico-Pabia CJ, Sporn J, Boucher M, Tourian KA. Effects of desvenlafaxine on blood pressure in patients treated for major depressive disorder: a pooled analysis. Curr Med Res Opin. 2015 Apr;31(4):809-20. doi: 10.1185/03007995.2015.1020365. Epub 2015 Mar 26. PMID: 25758058. [cited 2026 Mar 19]

19. Hengartner M,  Ploderl M,  Newer-generation Antidepressants and Suicide Risk …. published in the Journal of Psychotherapy Psychosomatics [published June 4, 2019] [cited 2026 Mar 19]

20. Pristiq US Patents Patent 8269040 Expiry published online (ND) [cited 2026 Mar 19]

21. Nabeel Aslam, Sobia Memon, Hani Wadei, Shehzad Niazi, P0150
EFFECT OF SEROTONIN REUPTAKE INHIBITORS (SSRIS) AND SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIS) ON BLOOD PRESSURE VARIABILITY USING 24 HOURS AMBULATORY BLOOD PRESSURE MONITORING, Nephrology Dialysis Transplantation, Volume 35, Issue Supplement_3, June 2020, gfaa142.P0150 [cited 2026 Mar 19]

22. Calle AM, Aguirre N, Ardila JC, Cardona Villa R. DRESS syndrome: A literature review and treatment algorithm. World Allergy Organ J. 2023 Apr 8;16(3):100673. doi: 10.1016/j.waojou.2022.100673. PMID: 37082745; PMCID: PMC10112187. [cited 2026 Mar 19]

23. Masuka JT, Mchunu N, Mkhize Z, Thandar Y, Mosam A. Selective serotonin reuptake inhibitor and serotonin-norepinephrine reuptake inhibitor associated cutaneous adverse drug reactions: A systematic review of case reports and case series. Australas J Dermatol. 2022 Feb;63(1):e13-e20. doi: 10.1111/ajd.13780. Epub 2021 Dec 27. PMID: 34958129. [cited 2026 Mar 19]

Originally Published Sep 13, 2018 by Diane Ridaeus


This content has been reviewed and approved by a licensed physician.

Dr. Samuel Lee

Dr. Samuel Lee is a board-certified psychiatrist, specializing in a spiritually-based mental health discipline and integrative approaches. He graduated with an MD at Loma Linda University School of Medicine and did a residency in psychiatry at Cedars-Sinai Medical Center and University of Washington School of Medicine in Seattle. He has also been an inpatient adult psychiatrist at Kaweah Delta Mental Health Hospital and the primary attending geriatric psychiatrist at the Auerbach Inpatient Psychiatric Jewish Home Hospital. In addition, he served as the general adult outpatient psychiatrist at Kaiser Permanente.  He is board-certified in psychiatry and neurology and has a B.A. Magna Cum Laude in Religion from Pacific Union College. His specialty is in natural healing techniques that promote the body’s innate ability to heal itself.

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Nothing on this Website is intended to be taken as medical advice. The information provided on the website is intended to encourage, not replace, direct patient-health professional relationships. Always consult with your doctor before altering your medications. Adding nutritional supplements may alter the effect of medication. Any medication changes should be done only after proper evaluation and under medical supervision.

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