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Revised Antidepressant WD Guidelines FDA (US) and NICE (UK)

Last Updated on November 4, 2025 by Diane Ridaeus

Alternative to Meds Editorial Team
Medically Reviewed by Dr Samuel Lee MD

Understandably, people want to know how long it will take to come off an antidepressant. The truth is there is no set time-line that fits everyone.

Alternative to Meds Center has spent the last 2 decades helping clients successfully come off antidepressant medications. As will be described more fully below, there are 2 important guidelines to success here, namely to prepare well, and to go slow. Read on for more important information that we recommend sharing with your prescriber. Or simply call/email us for more immediate assistance.


Your timeline is uniquely yours.
SSRI withdrawal revised guidelines
We would invite you to take a look at our high rates of success over the last nearly 2 decades. It is ATMC’s non-toxic approach to mental health and medication management that has helped our clients achieve success with their mental health goals. We followed the FDA revised guidelines for antidepressant withdrawal before they were revised! Whether or not you are looking for in-patient help, or are looking for resources that can help you closer to home, this article may help inform you for the best outcomes and in the steps you can take in your personal recovery planning.
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Three Problems With Older Antidepressant Withdrawal Guidelines, Timelines

It’s no secret that there are multiple factors that can hamper correctly estimating a predictable timeline for coming off antidepressant medications. It can be a complex and nuanced process, more for some than for others, to be sure. antidepressant withdrawal guidelinesThe first problem with older antidepressant withdrawal guidelines was that in the past, regulatory bodies seemed to discount or be unaware of the many difficulties that can be encountered. So, doctors simply passed on to their patients the regulators’ advice that antidepressant withdrawal will most probably be mild and “self-limiting” and might take a week or two. The idea was to cut your dose in half for a couple of days or a week, followed by another 50% cut, and after another week or so, just stop.7,11 This strategy is no longer an “official” FDA guideline for antidepressant withdrawal.

The second problem, and even worse, was doctors advising to “just stop, and it should be fine.” Studies now clearly show the majority of people taking antidepressants will have withdrawal symptoms when they stop. Regulators like the FDA and NICE have now officially revised the guidelines to clarify that fast or abrupt withdrawal of antidepressants is NOT recommended.2,4,5

The third problem was the notion that withdrawal symptoms were most likely evidence of “relapse.” One wonders if this train of thought had origins other than bona fide sources, as it meant doctors were re-prescribing drugs as a matter of course, a most welcome trend for drugmakers. Many researchers like Horowitz, Fava, Moncrieff and others have clearly stated more research is vital to gain a better understanding of antidepressant withdrawal mechanics and symptoms, so prescribers can distinguish withdrawal symptoms from relapse.6,8

Factors that Help Determine the Best Timeline for Antidepressant Withdrawal

The idea of a universal timeline for antidepressant withdrawal should be relegated to the myths of the ancient past. And even the regulators like the FDA and NICE in the UK have recently come to a more sensible approach to the subject. It’s going to be different for every individual.

Let’s look at what some of the variables can be in designing your timeline for safe and tolerable antidepressant discontinuation. Antidepressant withdrawal done incorrectly might be symbolized as the hellish experiences described in Dante’s Inferno. In very real terms, antidepressant withdrawal can be punishing beyond belief. To avoid these pitfalls, the following should be considered in estimating the length of time it may take to come off antidepressants safely. And also to determine the best strategies for success.

In general terms, 2 keys for successful antidepressant withdrawal are “to prepare” and “to go slow.”

Preparing for Coming Off Antidepressants

Taking stock of the person’s present condition can be instrumental in designing a workable plan for discontinuation. This could include checking on some basics like sleep, diet, and any ongoing stress factors before adjusting dosages.

get adequate rest for preliminary stages of antidepressant withdrawalIt is advisable to take some time off work/school to allow for adequate rest, at least for the preliminary stages of coming off antidepressant medications. Avoid stressful social commitments. This is time for you to heal. You may need to enlist the help of close family or friends to assist you with shopping, meal preparation, and household chores to take these burdens off you if that is possible. This is one reason why people opt for inpatient treatment if this can be arranged.

A productive next step would entail working with your prescriber. You need one who can take the time to plan your taper schedule correctly. You may need to take care of sleep and diet first, so that you are starting from a place where you are getting decent sleep and eating well. Exercise may be another beneficial preparation point, if only getting outside for daily walks or short sessions of stretching, yoga, Qigong, or other activities that you can manage.

If sleep is an issue, your prescriber may be able to offer you holistic or herbal sleep remedies. In extreme cases, a short course of medication for sleep might be necessary — for example, if a person has not slept well for months. Lack of sleep should be addressed before beginning a withdrawal program to whatever degree is manageable. A warm Epsom salt bath before retiring may also be beneficial. Get blue light and electronics out of the sleeping area. There are many drug-free ways to block noise and light that you may consider putting in place to get some improvements to sleep.

Assembling your team of helpers can be highly beneficial so you are starting from a less stressful position, even if it’s a couple of hours a day or a few days a week, to come in and help you with the logistics of daily life.

Talking Points for You and Your Prescriber that Follow the Revised FDA & NICE Guidelines

Working with your prescriber is your overall best strategy for planning successful antidepressant withdrawal that follows the revised FDA and NICE guidelines. If your prescriber is unwilling or feels incapable of helping you, find one who will. The following gives a list of things your prescriber should ask you about so that a slow and gradual withdrawal plan can be designed for you.

Factors to consider in antidepressant withdrawal:
  • points to consider in antidepressant withdrawalAge and general health of the patient, including co-occurring disorders
  • How long the medication has been taken, and the dosage
  • Whether multiple medications are being taken simultaneously
  • Genetic profile — a knowledge of polymorphisms affecting metabolism
  • The presence of toxic accumulations in the body
  • Sleep quality or lack thereof
  • Nutritional profile and diet

Unless the prescriber is an independent practitioner, modern doctors are very frequently operating under severe time limits, getting each patient in and out of the office as quickly as possible. The above list of considerations would obviously take more than a 15-minute interview to delve into, for an accurate snapshot that would help determine a correct estimate for a discontinuation timeline that ends favorably for the patient. Lab testing for nutritional deficits, toxic elements, and genetic factors may take some time — but will open many doors for choosing a correct set of strategies that will prove beneficial.

You will want to work with a professional who understands the importance of these points in designing your unique antidepressant time line.4,5

Commonly Reported Antidepressant Withdrawal Symptoms and Side Effects

One can study the most commonly reported antidepressant withdrawal symptoms, also called antidepressant discontinuation syndrome (ADS) by reading the antidepressant medication’s label carefully. The drug label will also indicate more rare side effects. It’s a very long list. For the sake of brevity, we’ll list out the ones found to be most commonly reported. We’ll also expand the hypothetical definition referred to as “F I N I S H” — a theoretical consensus put forward by a panel of psychiatrists in the late 1990s. They were beginning to notice some “troublesome” discontinuation symptoms of their patients. There were no clinical studies back then on coming off antidepressants, and “FINISH,” though incomplete, became a handy yardstick for prescribers to use.7 Modern prescribers have additional clinical data available to them, which if they study it, will enable them to understand the width and breadth of phenomena associated with antidepressant withdrawal more completely.1,3,9-12

Most commonly reported ADS and side effects of antidepressant discontinuation include:
  • Flu-like symptoms, i.e., muscle aches, lethargy, headache, general malaise
  • Insomnia
  • Nausea
  • Imbalance
  • Sensory disturbances, i.e., brain zaps, shivers, prickling skin
  • Hyper-arousal
  • Return of original symptoms
  • “Rebound” symptoms, much intensified compared to pre-medication
  • Anxiety
  • Dizziness, vertigo, lightheadedness
  • Crying spells
  • Irritability
  • Dizziness
  • Aggressive or impulsive behaviors

How have the FDA and NICE Guidelines for Antidepressant Withdrawal Changed?

While some researchers have been clearly sounding the alarm bells for decades, it has taken this long for the regulators to acknowledge that antidepressant withdrawal is a real and common medical problem. The previous approach of basically ignoring the subject has been replaced with much stronger guidelines including to never abruptly stop antidepressants. Instead, strong recommendations are now in place for a slow and gradual tapering of these medications.

ATMC’s Approach for Safe & Tolerable Antidepressant Withdrawal

ATMC has always approached antidepressant withdrawal by taking the time for a thorough assessment, pre-taper, as outlined above. The client’s medical history, genetic polymorphisms, dietary habits, burden of toxicity, checking for chronic sleep issues, are all important pieces of information in planning safe and tolerable antidepressant withdrawal. Comprehensive lab testing is also used to analyze these important data points.

ATMC's approach to safe & tolerable antidepressant withdrawal & recoveryOur medical and care team are ready to assist you in your quest for improved mental health in tandem with safe withdrawal from medication. If one’s original symptoms have not been addressed, there is little point in simply stopping medication as they will still be there. Finding root causes for the original symptoms and addressing these without drugs is prime real estate in recovery at ATMC.

Counseling, exercise, and holistic detox protocols are blended into each client’s program as well as a wealth of adjunctive comfort therapies to make the process much easier to tolerate, always under careful medical oversight. Nutritional deficits, toxic impairments to neurotransmitters, for example, are all addressed at ATMC for relief of original symptoms.

For more details on how ATMC addresses the fundamentals in antidepressant withdrawal so comprehensively, please visit our services overview and antidepressant withdrawal pages. Then give us a call and find out how easy it may be for you to enroll in the most cutting edge antidepressant withdrawal program available on the planet.

Other Helpful Resources for Antidepressant Withdrawal

We understand that not everyone is a candidate for inpatient treatment. If you are looking for help closer to home, please check out these 2 resources to find excellent help for antidepressant withdrawal that follows the revised guidelines from the FDA (US) and NICE(UK, International).

Visit ACAAM.org and IMMH.org

Sources:


1. Horowitz MA. Step change in guidance on withdrawing antidepressants. Br J Gen Pract. 2023 Apr 27;73(730):204. doi: 10.3399/bjgp23X732669. PMID: 37105756; PMCID: PMC10147439. [cited 2025 Nov 4]

2. Horowitz MA, Framer A, Hengartner MP, Sørensen A, Taylor D. Estimating Risk of Antidepressant Withdrawal from a Review of Published Data. CNS Drugs. 2023 Feb;37(2):143-157. doi: 10.1007/s40263-022-00960-y. Epub 2022 Dec 14. PMID: 36513909; PMCID: PMC9911477. [cited 2025 Nov 4]

3. Palmer EG, Sornalingam S, Page L, Cooper M. Withdrawing from SSRI antidepressants: advice for primary care. Br J Gen Pract. 2023 Feb 23;73(728):138-140. doi: 10.3399/bjgp23X732273. PMID: 36823051; PMCID: PMC9976819. [cited 2025 Nov 4]

4. NICE Guidelines for Stopping Antidepressants: Depression in Adults published 29 June 2023 [cited 2025 Nov 4]

5. Royal College of Psychiatrists Stopping Antidepressants published Mar 2024 [cited 2025 Nov 4]

6. Horowitz MA, Taylor D. Distinguishing relapse from antidepressant withdrawal: clinical practice and antidepressant discontinuation studiesBJPsych Advances. 2022;28(5):297-311. doi:10.1192/bja.2021.62 [cited 2025 Nov 4]

7. Schatzberg AF, Haddad P, Kaplan EM, Lejoyeux M, Rosenbaum JF, Young AH, Zajecka J. Serotonin reuptake inhibitor discontinuation syndrome: a hypothetical definition. Discontinuation Consensus panel. J Clin Psychiatry. 1997;58 Suppl 7:5-10. PMID: 9219487. [cited 2025 Nov 4]

8. Henssler J, Heinz A, Brandt L, Bschor T. Antidepressant Withdrawal and Rebound Phenomena. Dtsch Arztebl Int. 2019 May 17;116(20):355-361. doi: 10.3238/arztebl.2019.0355. PMID: 31288917; PMCID: PMC6637660. [cited 2025 Nov 4]

9. Fava GA, Gatti A, Belaise C, Guidi J, Offidani E. Withdrawal Symptoms after Selective Serotonin Reuptake Inhibitor Discontinuation: A Systematic Review. Psychother Psychosom. 2015;84(2):72-81. doi: 10.1159/000370338. Epub 2015 Feb 21. PMID: 25721705. [cited 2025 Nov 4]

10. Moncrieff J, Hobday H, Sørensen A, Read J, Plöderl M, Hengartner M, Kamp C, Jakobsen J, Juul S, Davies J, Horowitz M. Evidence on antidepressant withdrawal: an appraisal and reanalysis of a recent systematic review. Psychol Med. 2025 Jul 22;55:e191. doi: 10.1017/S0033291725100652. PMID: 40692314; PMCID: PMC12315658. [cited 2025 Nov 4]

11. Haddad P. Newer antidepressants and the discontinuation syndrome. J Clin Psychiatry. 1997;58 Suppl 7:17-21; discussion 22. PMID: 9219489. [cited 2025 Nov 4]

12. FDA drug label Zoloft (sertraline hydrochloride) approval 1991, revised December 2016 [cited 2025 Nov 4]


Originally Published November 5, 2025 by Diane Ridaeus


This content has been reviewed and approved by a licensed physician.

Dr. Samuel Lee

Dr. Samuel Lee is a board-certified psychiatrist, specializing in a spiritually-based mental health discipline and integrative approaches. He graduated with an MD at Loma Linda University School of Medicine and did a residency in psychiatry at Cedars-Sinai Medical Center and University of Washington School of Medicine in Seattle. He has also been an inpatient adult psychiatrist at Kaweah Delta Mental Health Hospital and the primary attending geriatric psychiatrist at the Auerbach Inpatient Psychiatric Jewish Home Hospital. In addition, he served as the general adult outpatient psychiatrist at Kaiser Permanente.  He is board-certified in psychiatry and neurology and has a B.A. Magna Cum Laude in Religion from Pacific Union College. His specialty is in natural healing techniques that promote the body’s innate ability to heal itself.

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