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Mental Health and Physical Health – Cross-Effects to Consider

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Medically Reviewed Fact Checked

Alternative to Meds Editorial Team
Medically Reviewed by Dr. Samuel Lee, MD

In many ways, physical and mental health can have reciprocal cross-effects. If one is neglected, the other can also mirror negative effects. Though it can be difficult at times, taking care of both ends of the spectrum of health can help ensure lasting benefits, both mental and physical.

Physical exercise and nutrition are both key players. A proactive approach to both mental and physical health can be a powerful ally in the quest for positive results across both of these important domains.


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Are There Cross-effects Between Physical Health and Mental Health?

Cross-effects between physical and mental health are well-documented in current clinical literature. In fact, a study published in the 2023 British Medical Journal concluded that co-morbidity is just about twice as prevalent in those who suffer from chronic mental illnesses.1

This conclusion was drawn from a massive study that analyzed statistical data from over 7 million participants across multiple regions and countries including Europe, Asia, and North America. The results showed a nearly two-fold risk for poor physical health in the group whose medical records also showed a history of severe or chronic mental health disorders.

What Role Does Physical Exercise Play in Supporting Mental Health?

In comparison to the above, a 2024 review of nearly 300 studies published in the International Journal of Behavioral Nutrition and Physical Activity demonstrated clearly that persons who engaged in regular physical activity and exercise reported better mental health conditions than those who did not.2 Many studies have shown similar outcomes, and in a general sense, we can conclude that physical exercise and activity generally makes people feel better — emotionally, as well as physically. Getting the body in motion regularly is positive for cardiac and metabolic health, prevention or alleviation of depression and anxiety disorders, and has been proven therapeutic in the treatment of psychiatric disorders such as schizophrenia.5

Of note, in another very broad study involving over 600,000 participants, when leisure-based or transport-related physical activity involved things like walking to work, pleasure cycling, hiking, and swimming, the positive mental health benefits were clear. However, when the physical activity was work-related, or where housework was involved, there was a distinct rise in negative mental health impacts such as stress and distress, especially in working women.3

A 2020 study out of Finland showed that men gained the most positive mental health benefits from group sports vs activities done solo, and also showed greater benefits for mental wellness from leisure-related physical activity, vs occupational-related physical activities.4

Beneficial cross-effects on mental health from physical & leisure-based activity included:

  • group leisure exercise has many mental and physical benefitsEmotional well-being
  • Self-esteem
  • Self-efficacy
  • Physical self-worth & body image satisfaction
  • Psychological resilience
  • Positive social connections
  • Absence or reduction of pain
  • Absence or reduction of fatigue
  • Absence or reduced stress, emotional distress
  • Prevention of depression, anxiety
  • Positive therapeutic effects in treating schizophrenia

Nutrition’s Powerhouse Role in Physical and Mental Wellness

Sound nutrition supports physiological health. But often overlooked, it is a key player in not only alleviating mental health symptoms, but in preventing them! Lab testing is an efficient way to discover if nutritional deficiencies need to be corrected. Both changes in diet and supplementation can be instrumental in naturally correcting any such deficiencies. nutrition has profound effect on both mental health and physical healthA good nutritional status supports not only physical health, but can prevent physical conditions that may not only impact mobility and longevity, and ultimately can take a toll on mental health as well.

When a person is ill, it’s pretty hard to be happy at the same time. These domains are both positively affected by paying attention to a correct nutritional plan.

On one hand, what we consume can directly or indirectly lower our mood, cause blood sugar spikes and crashes, contribute to anxiety, and other stress factors that make us feel mentally unwell. Similarly, low mood is closely connected with lack of activity and motivation.

On the other side of the picture, correct food and supplement choices in the daily diet can positively support mental wellness, brightness, and energy needed for an active lifestyle. Some physicians, especially the holistic “green” psychiatrists, are now beginning to prescribe both exercise and diet changes instead of prescription medication for psychiatric symptoms such as insomnia, anxiety, and depression.6,7

Dietary Choices that Wreck Mental Wellness, vs Ones that Support a Calm Mood, and Give us Energy

the body needs proper, clean hydration everydayGeneral recommendations for these positive effects include avoiding refined carbohydrates in large quantities, and cutting out sugary or chemically laden desserts and chemically processed snack foods that are full of empty calories but lack nutritional value. These foods can burden the insulin producing hormones in the body, and corrupt many vital organ functions. Physical problems such as overweight, diabetes, cardiovascular diseases, jitteriness and subsequent fatigue of blood sugar spikes and crashes, corrupted hormone function, and others are associated with a poor diet.

However, eating a wide variety of raw or unprocessed fresh fruits and vegetables, good quality proteins, fermented foods to support gut health, and staying well hydrated are good measures to ensure the body is getting everything it needs for calm energy, proper cardiac function, hormone production, and a healthy gut. For mental wellness, these are important pieces of the puzzle.8

Find out more about specific dietary choices for mental health as recommended by ATMC.

Supplements to Consider for Depression and Anxiety

While supplements alone aren’t going to reverse deep-seated mental conditions immediately, they can certainly assist in the reversal of symptoms like depression and anxiety that arose from factors including poor nutrition, even if underscored by a lifetime of no exercise and unhandled mental trauma.

NAD+ IV therapy and IV nutrient therapy provide relief for unwanted symptomsStudies have shown that application of nutritional supplements such as Omega-3 fatty acids, B vitamins, magnesium, probiotics, zinc, and others can be significantly beneficial in treating major depression.9 Speak to a naturopath in choosing the most beneficial supplements for your personal situation.

Perhaps not surprisingly, similar recommendations are provided by clinical researchers for anxiety relief, including a foundational diet high in vitamin and mineral content, quality proteins, and relatively unprocessed foods, supplemented with Omega-3s, zinc, magnesium, selenium, tryptophan, and probiotics for gut health. The gut is where most of our neurotransmitters are produced so it’s a key part of the nutritional pathway to good mental and physical health.

As part of a well-planned recovery program, supplements such as NAD+ in IV form and nebulized glutathione can provide great relief for unwanted physical and mental symptoms. Supplements like these can also play a substantial supporting role when coming off psychiatric medications in a managed setting like Alternative to Meds Center.

Nutrition that Can Aid in Insomnia

There can be many contributing causes resulting in insomnia. When it persists too long, it can have disastrous physical and mental health effects. In the case of persistent insomnia, the most important therapeutic step to take is to discover the root cause or causes for the condition.

correct nutrition can help resolve insomniaThis is the way ATMC addresses such chronic symptoms. Supplements like tryptophan or melatonin (precursors to serotonin) may have a limited benefit, as well as drinking chamomile tea, or other soothing herbal preparations to help get the body prepared for sleep. For some people, these work very well and are beneficial without the risk of side effects that can come from prescription medications.

However, for more chronic issues, real relief is going to come from addressing the actual underlying reasons for your insomnia.

In addition to possibly being related to poor nutrition, insomnia can also be medication-induced, from certain heart meds, food allergies, too much caffeine, or other stimulants. Insomnia could be stress-related, or could even be a symptom of using sleeping pills for too long, more than a few days or weeks.

The best solution is to discover the root cause and then address that appropriately. This is the approach at ATMC, using a combination of lab testing and other assessments to pinpoint the actual root cause for your symptoms.

What You Should Know about Toxins and Your Health

We get exposed to toxic substances nearly daily from pesticide contamination, air and water pollution, chemicals in processed foods, and even from medications we have taken under doctor’s care.

Toxic exposure can result in physical and mental health symptoms, and these can mimic mental illness, and result in a misdiagnosis. Many of our clients have discovered this was the case in their own history. Once again, lab testing can isolate these toxic accumulations, and a proper and thorough cleansing process can purge them from the body. This is where true and lasting relief of symptoms can occur. After cleansing in the “Detox Shoppe” spa with sauna, oral chelators, ionic foot baths, colon hydrotherapy, and other methods, clients typically report higher energy, better mood, better sleep, and physically feeling better than they ever did on medication.

Want to Find Out More about Therapeutic Programs at ATMC?

You can find out more about ATMC’s amazing range of therapeutic programs including medical oversight during medication withdrawal with a host of helpful adjunctive treatments that are nutritional, and orthomolecular and environmental medicine-based. You can optimize your mental health without relying on prescription medications and their sometimes horrific side effects.

ATMC residence in Sedona ArizonaATMC knows that there are far superior ways to get relief of symptoms than a lifetime of psychiatric medications that typically bring on other problems, and have a limited timeline of efficacy. We do the investigative work to isolate root causes for symptoms, and once these are addressed, there is no further need for the numbing action of medications. Your mental wellness is our main priority.

In a pristine, friendly atmosphere, nestled in the beautiful surrounds of the Red Rock Mountains of Sedona, you can look forward to a relaxed and productive journey to a better you. You’ll have the dedicated care of professional staff at your side every step of the way.

Call us anytime 24/7 to find out more about ATMC’s programs that are designed to address the cross-effects between physical and mental health in effective, holistic ways. It may be easier than you ever imagined to enroll at the center, and enjoy the relief that proper diet, supplementation, and toxic clearing can have on both the physical body and your mental and emotional health. Call us today!

CD’s Success Story

I began taking psych meds at age 16 to fight chronic head pain. I experimented with some forty meds until I settled on Cymbalta and Depakote. I soon added Ambien and Toradol to the mix. This continued for almost a decade until the head pain became unbearable and I started taking opiates: morphine, Percocet, and increasingly stronger doses of codeine. Eventually I reached overdose levels and my body went into shock. I quit the opiates cold turkey further exacerbating the problem and sending me into a psychotic state.

I entered a mental hospital and then transitioned into a partial hospital program for four months. During my stay there I increased the number of psych meds to nine. Sensing my life was once again threatened, I begin looking for detox options.

After doing thorough research, including seeking the advice of Dr. Peter Breggin, I decided to go to ATMC in Sedona, Arizona. When I arrived I was shaking uncontrollably from the lithium and from nervous spasms. The shakes were so pronounced that I had trouble feeding myself and my neck and back were sore from the constant shaking.

During my two months at ATMC, the medical staff helped me reduce and eliminate my psychiatric medications. The program components that helped me the most were the environmental medicine ridding my body of toxins, the nutritious food geared towards healing brain chemistry, the vitamins/supplements, and the nutrition/fitness education so I could sustain my new state of being for a lifetime. In addition, the staff I found to be always wanting to help me and get me through it.

I feel more vibrant than I have felt in thirty years. My shakes are gone and I no longer fear for my life. I am no longer enslaved to psych meds. Gaining mastery of my mind and nerves is the greatest accomplishment I have achieved in my life.

I know I could not have come this far by my own wits. In fact, I was at wits end before I came to ATMC. The loving support I received there helped me transform and reclaim the best of myself. I will always feel indebted to ATMC and feel part of the extended ATMC family.

C.D. – ATMC graduate 

Sources:


1. Pizzol D, Trott M, Butler L, Barnett Y, Ford T, Neufeld SA, et al. Relationship between severe mental illness and physical multimorbidity: a meta-analysis and call for action. BMJ Mental Health. 2023;26:e300870. https://doi.org/10.1136/bmjment-2023-300870 [cited 2025 Aug 26]

2. White RL, Vella S, Biddle S, Sutcliffe J, Guagliano JM, Uddin R, Burgin A, Apostolopoulos M, Nguyen T, Young C, Taylor N, Lilley S, Teychenne M. Physical activity and mental health: a systematic review and best-evidence synthesis of mediation and moderation studies. Int J Behav Nutr Phys Act. 2024 Nov 28;21(1):134. doi: 10.1186/s12966-024-01676-6. PMID: 39609855; PMCID: PMC11603721.[cited 2025 Aug 26]

3. White RL, Babic MJ, Parker PD, Lubans DR, Astell-Burt T, Lonsdale C. Domain-Specific Physical Activity and Mental Health: A Meta-analysis. Am J Prev Med. 2017 May;52(5):653-666. doi: 10.1016/j.amepre.2016.12.008. Epub 2017 Jan 30. PMID: 28153647.[cited 2025 Aug 26]

4. Appelqvist-Schmidlechner K, Vaara JP, Vasankari T, Häkkinen A, Mäntysaari M, Kyröläinen H. Relationship between different domains of physical activity and positive mental health among young adult men. BMC Public Health. 2020 Jul 16;20(1):1116. doi: 10.1186/s12889-020-09175-6. PMID: 32677931; PMCID: PMC7364501.[cited 2025 Aug 26]

5. Schuch FB, Vancampfort D. Physical activity, exercise, and mental disorders: it is time to move on. Trends Psychiatry Psychother. 2021 Jul-Sep;43(3):177-184. doi: 10.47626/2237-6089-2021-0237. Epub 2021 Apr 21. PMID: 33890431; PMCID: PMC8638711.[cited 2025 Aug 26]

6. Burrows T, Teasdale S, Rocks T, Whatnall M, Schindlmayr J, Plain J, Latimer G, Roberton M, Harris D, Forsyth A. Effectiveness of dietary interventions in mental health treatment: A rapid review of reviews. Nutr Diet. 2022 Jul;79(3):279-290. doi: 10.1111/1747-0080.12754. PMID: 35796181; PMCID: PMC9545734.[cited 2025 Aug 26]

7. Escobar-Roldan ID, Babyak MA, Blumenthal JA. Exercise Prescription Practices to Improve Mental Health. J Psychiatr Pract. 2021 Jul 28;27(4):273-282. doi: 10.1097/PRA.0000000000000554. PMID: 34398577.[cited 2025 Aug 26]

8. Muscaritoli M. The Impact of Nutrients on Mental Health and Well-Being: Insights From the Literature. Front Nutr. 2021 Mar 8;8:656290. doi: 10.3389/fnut.2021.656290. PMID: 33763446; PMCID: PMC7982519.[cited 2025 Aug 26]

9. Martínez-Cengotitabengoa M, González-Pinto A. Nutritional supplements in depressive disorders. Actas Esp Psiquiatr. 2017 Sep;45(Supplement):8-15. Epub 2017 Sep 1. PMID: 29171639.[cited 2025 Aug 26]

10. Fernández-Rodríguez M, Rodríguez-Legorburu I, López-Ibor Alcocer MI. Nutritional supplements in Anxiety Disorder. Actas Esp Psiquiatr. 2017 Sep;45(Supplement):1-7. Epub 2017 Sep 1. PMID: 29171640.[cited 2025 Aug 26]


Originally Published August 29, 2025 by Diane Ridaeus


This content has been reviewed and approved by a licensed physician.

Dr. Samuel Lee

Dr. Samuel Lee is a board-certified psychiatrist, specializing in a spiritually-based mental health discipline and integrative approaches. He graduated with an MD at Loma Linda University School of Medicine and did a residency in psychiatry at Cedars-Sinai Medical Center and University of Washington School of Medicine in Seattle. He has also been an inpatient adult psychiatrist at Kaweah Delta Mental Health Hospital and the primary attending geriatric psychiatrist at the Auerbach Inpatient Psychiatric Jewish Home Hospital. In addition, he served as the general adult outpatient psychiatrist at Kaiser Permanente.  He is board-certified in psychiatry and neurology and has a B.A. Magna Cum Laude in Religion from Pacific Union College. His specialty is in natural healing techniques that promote the body’s innate ability to heal itself.

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Medical Disclaimer:
Nothing on this Website is intended to be taken as medical advice. The information provided on the website is intended to encourage, not replace, direct patient-health professional relationships. Always consult with your doctor before altering your medications. Adding nutritional supplements may alter the effect of medication. Any medication changes should be done only after proper evaluation and under medical supervision.

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