New Regulations to Inform Patients about Sexual Side Effects from SSRI Antidepressants
Sexual side effects from SSRI antidepressants have been a well-documented liability in the medical literature for quite a long time.6 PSSD is the newest of these antidepressant-related side effects to be recognized. Yet, according to the experts in the field, most prescribers are likely unaware of this phenomenon. As a consequence, their patients may not be fully informed of this and other risks of sexual dysfunction after SSRI use or SSRI withdrawal. According to the research, sexual side effects are associated with not only SSRIs, but also SNRIs, TCAs (tricyclics), and other classifications of antidepressant medications.
As far back as 2019, the European Medicines Agency (equivalent of the FDA in the US) called for updated patient/prescriber information on PSSD to be added to packaging for a very long list of drugs.6
New Patient Guidelines regarding PSSD (persisting sexual side effects after antidepressants) was ordered for these drugs:
- Duloxetine
- Fluoxetine
- Citalopram
- Vortioxetine
- Escitalopram
- Fluvoxamine
- Sertraline
- Desvenlafaxine
- Paroxetine
- Venlafaxine
- Milnacipran
- Clomipramine
- all SSRIs
- all SNRIs
Countries that have Added Warnings Regarding PSSD to Drug Packaging
Not every doctor or patient studies drug packaging thoroughly. But regulatory bodies have taken steps to mandate updated information about PSSD and other sexual risks on drug packaging. If you live in any of the countries listed below, there is information you can read, and encourage your prescriber to read if necessary.
If you live in the USA you will have to inform your prescriber yourself, as the warnings are missing on drug labels.
Medical Agencies from many around the world that have added PSSD warnings include:
- European Medical Agency (2019)
- HPRA in Ireland (2019)
- MHRA in the UK (2019)
- Health Canada (2021)
- Hong Kong Dept of Health (2022)
- Australian Dept of Health (2024)
- Malaysian Pharmaceutical Regulators (2025)
As of December 2025, FDA regulators have kept PSSD warnings hidden from the public, although information letters about PSSD risks associated with antidepressants were sent back in 2019.
Treatment Options for Neurotoxin Exposures
Treatment for PSSD is being researched. Drug companies are probably desperately searching for “some drug, any drug” that will reverse the condition. According to large clinical studies, none have been found.9,10 Likely, none will be found. Antidepressants are not healing agents. They are numbing agents, and can injure the CNS (central nervous system). When a substance damages neurons and receptors, that substance is called neurotoxic. There are many, many neurotoxins we can be exposed to in everyday life, let alone from medication.
However, a basic understanding of how antidepressants may disable neurotransmission can lead to helpful methods to reverse and heal damaged neuronal function. The CNS, including the brain, can adapt and make improvements in function — but the basic building blocks and raw material must be provided to be able to accomplish that.
No drug can create hormones and neurotransmitters. There are, however, substances that can aid in neurotransmitter rehabilitation that are found in foods, and supplementation.
Where neurotoxin exposure has occurred, neurotoxin removal has been shown effective for supporting the natural healing process.
ATMCs Approaches to Natural Healing
ATMC has been helping people with mental health for nearly 20 years, with great success. The foundational principles on which treatment programs are built do not depend on labels, or drug-based treatment.
The root cause of any non-optimum condition must be explored in order to arrive at a solution that works. Not by disabling nerve endings or numbing symptoms with more drugs.
Many of our clients have suffered for years with chronic conditions that have not responded to drug-based treatment. In fact, in many cases, drugs did further harm. Improperly done medication withdrawal is renowned for persisting difficulties that can be avoided and overcome when proper tapering methods are employed. Our goal is to help a client find and treat root causes for troubling symptoms. This can mean safe medication withdrawal, therapeutically effective diet correction and supplementation based on orthomolecular medicine, toxin removal, and a wide range of holistic psychological therapies and physical exercise and comfort therapies that can reduce stress, boost mood naturally, improve quality of life, and kick-start many facets of recovery.7,8 Find out more about cold-plunge therapy, sound healing therapy, Equine therapy, and much more on our services pages.
Whatever persisting symptoms one is experiencing, you can call us for treatment options that can boost your progress on your personal healing journey. ATMC is insurance friendly, and our hand-picked staff is dedicated to helping you. Call today for more information that may help guide your path to natural mental health, without relying on medication for life.