Clozaril can cause certain side effects and Clozaril withdrawal symptoms that may be difficult to navigate without assistance or guidance. The drug is not usually a first-line treatment choice but is more often used as an alternative choice where other prescriptions did not work or were not well tolerated due to severe reactions.
There are many important health reasons why it would be wise to research a drug before either starting or stopping a prescription drug, especially one as potent as Clozaril. Below you will find information on these and other topics that may be helpful in understanding more about Clozaril and how the drug works.
SPECIAL NOTE: As with all leftover, expired or unused prescription medications, please remember not to flush them or place them in regular garbage containers, and do not otherwise allow them to enter the water system in your community. Ask your local friendly pharmacist about the best way to dispose of medications so you can help protect the environment and the health of people around you.
Clozaril is used in the treatment of certain mental disorders, where other (usually at least two) other antipsychotic medications have not worked, or where the side effects were too harsh and could not be tolerated by the patient. A candidate for a prescription of Clozaril may be someone diagnosed with treatment-resistant conditions such as:
Clozaril is the brand name for the active ingredient, clozapine. Other brand names include Clopine, Clozapine Synthon, and FazaClo.
There are hundreds of known side effects for antipsychotic medications. We will list Clozaril-specific side effects both physiological (generally from highest risk on down), and psychological or mixed adverse effects, with the caution that this is not a complete list, as follows:
A significant number of individuals stop Clozaril due to side effects that become intolerable and outweigh any perceived benefit.
Except in circumstances where a life-saving intervention indicates sudden cessation, as discussed on more detail below in the section entitled “Discontinuing/Quitting Clozaril”, the FDA advises never to abruptly stop taking an antipsychotic agent such as Clozaril.
Withdrawal symptoms can be mild or severe and may begin quite soon after forgetting a dose, or if tapering from Clozaril, or they may happen after a considerable lapse of time has occurred. Constant monitoring is considered a best practice for coming off antipsychotic medications.
When coming off Clozaril (clozapine), even at a slow taper, here are some of the reactions that can occur, and should be closely monitored:
There are circumstances where immediate withdrawal of Clozaril is medically needed as a life-saving intervention. These include potentially life-threatening adverse reactions to the drug which are delineated in detail under the adverse effects section, for instance, cardiovascular compromise, risk of stroke, signs of tardive dyskinesia, and other severe reactions.
In all other cases, gradual Clozaril tapering methods are recommended for coming off the drug.
Always seek medical guidance and direction from your doctor before making changes to medications.
Below you will find information concerning some of the most asked questions about the antipsychotic drug Clozaril (clozapine). It is always recommended to research a medication as thoroughly as possible before starting a prescription and ask your doctor for more information about any questions you may have as regards your own health and medication history as well.
Our center specializes in treatment using holistic and natural methods for improving mental health. Where prescription drugs have not provided all the answers, or have caused unwanted adverse effects, we can help a person to safely and gently taper from and recover from these medications.
Dependence on psychiatric medications is sometimes compared synonymously to addiction. While the treatments for these conditions can overlap, there are also differences that must be taken into account in treating dependence that has developed when taking an antipsychotic medication, versus drug abuse and addiction.
Dependence on a potent antipsychotic drug must be treated with caution with respect to the risks that can accompany even a slow taper. We have helped clients overcome these formidable barriers utilizing a gentle taper, supported by nutrition-based, individualized, compassionate treatment methods.
Colonic hydrotherapy and other gentle remedies are available, which could be quite helpful where certain drugs, such as antipsychotics are prone to cause severe constipation. Constipation is not only uncomfortable, it can rob the body nutritionally, which once resolved can bring great relief and allow the body to begin to return to normal function again.
One of the most helpful treatments available to clients at Alternative to Meds Center is called holistic neurotransmitter replacement therapy. Using lab testing to isolate neurotoxic accumulations in the body, these are then purged using a highly effective but extremely gentle process of elimination. Nutritional support is also of great importance, as it gives the body what it needs to restore the neurochemical balance in a natural way. These methods are all done in our beautiful inpatient treatment facility, resulting in a comfortable retreat-styled transformative experience.
More information is made freely available on request regarding our cutting edge, safe and comfortable methods that apply to medication withdrawal. We invite you to discover more about the effective and healthy protocols in use at the center for the benefit of all our clients at Alternative to Meds Center with whom we share the goal of recovery of natural mental health.
1. Novartis Pharmaceuticals Corp Clozaril Prescribing Information, 2004 Nov
2. Dziedzicka-Wasylewska M1, Faron-Górecka A, Górecki A, Kuśemider M Mechanism of action of clozapine in the context of dopamine D1-D2 receptor hetero-dimerization—a working hypothesis. Abstract, NCBI Pub Med, 2008 Sep-Oct
3. Diamond A Consequences of Variations in Genes that affect Dopamine in Prefrontal Cortex NCBI 2007 Sep 17
Dr. Motl is currently certified by the American Board of Psychiatry and Neurology in Psychiatry, and Board eligible in Neurology and licensed in the state of Arizona. He holds a Bachelor of Science degree with a major in biology and minors in chemistry and philosophy. He graduated from Creighton University School of Medicine with a Doctor of Medicine. Dr. Motl has studied Medical Acupuncture at the Colorado School of Traditional Chinese Medicine and at U.C.L.A.