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Clozaril Withdrawal

It is uncommon for a medical professional to truly have the expertise to navigate a Clozaril withdrawal.

Antipsychotics like Clozaril (also known as Clozapine), even if indicated during a time of demonstrable crisis, does not always mean that a lifetime of being medicated is warranted.

Are you really your Diagnosis?


Alternative to Meds has been the expert on Clozaril withdrawal for over 15 years. We have published evidence regarding our success. Underlying issues can in many cases be addressed in much less toxic ways. We find that frequently there were medical conditions, or that the original factors that contributed to the crisis have since shifted, were diagnosed prematurely or even misdiagnosed.
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Help for Clozaril Withdrawal at Alternative to Meds Center

At Alternative to Meds Center rehab, the methods of Clozaril withdrawal help that are employed relieve uncomfortable symptoms of discontinuation and make this process much easier in general. Would you love to see yourself or someone you love start living life in ways you know must be possible? We know for a fact that other, better solutions are available than taking psychiatric drugs for the rest of your life. Clozaril is the brand name for Clozapine, a powerful antipsychotic medication prescribed for schizophrenia, and a powerful Clozaril withdrawal syndrome can come along with the decision to stop taking this medication.

When is Clozaril prescribed?

People usually are first prescribed these drugs during a manic break, or after other drugs have failed to be effective. Though antipsychotics may seem effective at controlling symptoms during the onset, sometimes the cons outweigh the pros, as these drugs usually are not tolerated well with prolonged use. Clozaril withdrawal symptoms include returning schizophrenia, psychoses, psychotic episodes, mania, insomnia, trouble swallowing, tightening of the throat, feeling short of breath, trouble breathing, muscle spasms, extreme anxiety, paranoia, fear, nausea, vomiting, feelings of unreality, and changes in perception just to name a few.1,4

Individuals medicated on an antipsychotic generally feel incapable of performing in life as they want to, find it difficult to set and meet goals, and have trouble perceiving reward from life. These effects are often considered better than having to deal with antipsychotic withdrawal, or not being able to sleep in a case of insomnia, so many stay on the drug. Gradually lowering the dosage of an antipsychotic drug will help to prevent and lessen withdrawal symptoms.

About Clozaril Rapid Onset Withdrawals

Clozaril has a relatively short 4- to 12-hour half-life and can have a rapid onset of withdrawal if abruptly stopped. Never stop Clozaril cold turkey. This antipsychotic should not be suddenly stopped, and only should be discontinued under carefully supervised medical Clozaril withdrawal help.3,4

When is Clozapine typically prescribed?

Clozapine is usually only prescribed for people who don’t respond well to other antipsychotic drugs and is prescribed with caution because of potentially dangerous side effects and acute Clozaril withdrawal effects. There are justified reasons why a person would want or need to stop taking this drug, one being that Clozapine can cause a dangerous reduction in the white blood cell count. White blood cells are what fight infections, and with a severe reduction in white blood cells, a person can develop a serious infection that could even result in death. In the case of a life-threatening situation regarding the count of white blood cells, Clozapine withdrawal must be done immediately.3,4

clozaril withdrawal

How does Clozapine affect neurochemistry?

This antipsychotic restricts the excitatory neurotransmitter called dopamine which changes the brain at the synapse. The space where one nerve communicates to another is the synapse. Dopamine is what arouses the originating nerve’s impulsivity to the receptors of the next nerve. When the drug has caused dopamine action to become lowered, the neurology is altered. The body responds in a compensatory fashion by making additional dopamine receptors.2

When the individual stops taking the drug, additional dopamine is released, but now is affecting excessive numbers of dopamine receptors. Using caffeine/coffee, nicotine/cigarettes, and sugar can magnify this effect, as these were very likely the things the individual may have been doing to feel stimulated while on the drug. This can contribute to extreme withdrawal symptoms or result in being hospitalized. People are commonly told that they need to take medication for the rest of their life. All of this can be very discouraging. The founder of Alternative to Meds Center has had personal experience down this path. There are safer, better alternatives.

Holistic Methods During Clozaril Withdrawal Treatment

For successful Clozaril discontinuation, we employ numerous methods. To start, we lab-test to see what might have caused the initial symptoms. This is where toxicity is usually found to be the cause. Toxicity can result from genetics or environmental sources, so we then aim to clear out these toxins. Therefore, we have to restrict processed food, sugars, and caffeine, and utilize supplements that specifically benefit these individuals by supporting aspects of the neurochemistry that are inhibitory.

Our rehab program stabilizes the neurochemistry through natural substances, removal of accumulated neurotoxins, and use of amino treatments, targeted nutritional treatment, peer support, yoga, exercise, massage, personal training, and holistic treatments. These therapies are integral to address anticipated symptoms of withdrawal during Clozaril tapering. The person’s medication can be decreased slowly once the individual feels the sedative and stabilizing effects of the therapies. We encourage you to call us to learn more about the sort of Clozaril withdrawal help that is available.


    1. Howland RH, “Potential Adverse Effects of Discontinuing psychotropic drugs, Part 3, Antipsychotic, dopaminergic, and mood-stabilizing drugs,” US National Library of Medicine, National Institute of Health, PubMed, 2010 Aug [cited 2019 Oct].
    2. Meitzer, H. “What’s atypical about atypical antipsychotic drugs?,” NIMH, 2004 Apr [cited 2019 Oct].
    3. Cornett, EM, PhD; Novitch, M, BS; Kaye, AD, MD, PhD; Kata, V, MS; Kaye, AM, PharmD4 “Medication-Induced Tardive Dyskinesia: A Review and Update,” authors NCBI, Ochsner Journal, 2014 Summer [cited 2019 Oct].
    4. FDA label information clozaril/Clozapine, [accessed 2019 Oct].


This content has been reviewed and approved by a licensed physician.

Dr. Samuel Lee

Dr. Samuel Lee is a board-certified psychiatrist, specializing in a spiritually-based mental health discipline and integrative approaches. He graduated with an MD at Loma Linda University School of Medicine and did a residency in psychiatry at Cedars-Sinai Medical Center and University of Washington School of Medicine in Seattle. He has also been an inpatient adult psychiatrist at Kaweah Delta Mental Health Hospital and the primary attending geriatric psychiatrist at the Auerbach Inpatient Psychiatric Jewish Home Hospital. In addition, he served as the general adult outpatient psychiatrist at Kaiser Permanente.  He is board-certified in psychiatry and neurology and has a B.A. Magna Cum Laude in Religion from Pacific Union College. His specialty is in natural healing techniques that promote the body’s innate ability to heal itself.

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