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Fanapt Alternatives

This entry was posted in Antipsychotic on by .
Medically Reviewed

Last Updated on November 29, 2021 by Diane Ridaeus

Alternative to Meds Editorial Team
Medically Reviewed by Dr Samuel Lee MD

Rarely does a medical professional have the training and expertise — much less the time — to put together a comprehensive program for Fanapt alternatives in treatment.

Atypical antipsychotics like Fanapt may have been needed during a time of demonstrable crisis. However, one can examine the feasibility of Fanapt alternatives to avoid a lifetime of being medicated if that is not what the person wants.

Do Your Symptoms
Require Fanapt?

successful fanapt alternatives
Alternative to Meds has been the expert on antipsychotic alternatives for over 15 years. We have published evidence regarding our success. Underlying issues may have been overlooked. There are many less toxic ways to help address symptoms than forever relying on drugs. We find that often, a prescribing physician may have overlooked certain medical or environmental conditions, especially as this drug is frequently prescribed during the height of a crisis. Once the person has stabilized somewhat, perhaps that marks the time to consider Fanapt alternatives.
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What is Meant by Fanapt Alternatives?

We are not talking about better drugs, or different drugs, or combining Fanapt® with more drugs, or electroconvulsive therapy. At Alternative to Meds Center, we offer our clients the opportunity to discover and treat the real underlying and contributing factors that threw a person over the edge into unmanageable psychosis, or other severe conditions that led to a physician prescribing a drug such as Fanapt.

Fanapt is licensed by the FDA to treat schizophrenia in adults.17 Fanapt is sometimes prescribed off-label for other conditions, such as treating anxiety, bipolar depression, MDD, ADD, dementia, eating disorders, insomnia, OCD, PTSD, Tourette’s syndrome, substance abuse, autism, and others.18,19,20 

Unfortunately, physicians are not well-trained in the subject of alternatives to drugs, and even the FDA admits it doesn’t know how atypical antipsychotic medications actually “work”, but there are many effective alternatives to Fanapt and similar drugs, that may be preferred as they do not carry with them the risks of side effects or lack of efficacy. 

The clinical trials that preceded the approval of Fanapt were 4 weeks and 6 weeks in duration, but still showed many concerning adverse effects. In animal studies, Fanapt use prompted higher incidences of stillbirths and fetal deformities, as well as cancerous tumors in breast, pituitary, and pancreatic tissues, and maternal deaths. In the elderly population, risks included stroke and death which occurred more frequently than in the placebo population in the trial. Other findings in the trials showed decreased fertility rates, increased cardio and blood pressure impairments, neurological disorder symptoms, and many other adverse effects.17 To avoid these risks, one may wish to consider alternative treatments that carry no such adverse health consequences.  

Effective Alternatives to Fanapt

Alternatives to antipsychotic medication may not have been available at the time of beginning a prescription of Fanapt when a mental health crisis was in motion. After the crisis has passed, it may be desirable to consider some non-drug-based treatment options to address psychiatric symptoms, and these may also provide effective options as part of an overall holistic tapering program when considering coming off a drug such as Fanapt.  Despite reviews finding no efficacy for doing so,20 Fanapt is frequently prescribed off-label for symptoms that may be better managed or eliminated through judicial use of non-drug-based treatments. The following are examples of non-prescription-based alternatives to Fanapt that may be able to address troublesome symptoms safely. 

  • Change in diet: choose organic (pesticide-free), eliminate chemical additives and processed foods, also check for food allergies that can manifest as psychiatric symptoms and lead to misdiagnoses.13,21,22,27 
  • Blood sugar: control blood sugar spikes and crashes by avoiding high glycemic foods. Blood sugar management is an important aspect of reducing unwanted symptoms.3,15,16 
  • Remedy vitamin/mineral/micronutrient deficiencies: Common examples are Vit D, magnesium.23,28-32
  • Drink water, stay hydrated: Symptoms of dehydration and salt depletion are often misdiagnosed as psychiatric in nature.9,10
  • Supplementation: support healthy microbiome and neurochemistry using probiotics, fermented foods, Kava, herbal teas, passionflower extract, GABA, taurine, and other amino acids as examples, selecting products that can meet individualized desired outcomes. 23,28-32,36.43
  • Counseling: CBT has been documented in studies as more therapeutic than pharmaceuticals. There are many forms of talk therapy to consider for your unique needs.24
  • Cleanse toxic accumulations: sauna, chelation, ionic foot baths are some options to purge these destructive agents from the body.1,4,5,25,26,42
  • Check for toxic mold exposure: mold exposure can induce unwanted symptoms and is often overlooked before issuing a mental illness diagnosis.11,40,41
  • Relaxation therapies: mindfulness meditation, yoga, Reiki, therapeutic massage, acupuncture, have all been shown efficacious for unwanted symptoms like anxiety, tension, depression, and insomnia.33-35
  • Bright light therapy, exposure to sunlight, getting outdoors: mental health benefits are near-immediate, and extremely long-lasting, without side effects of pharmaceutical drugs.38,39,44.
  • Exercise: mental health benefits can be robust with even mild or moderate exercise daily or working up to several times a week.37
  • Insomnia and mental health symptoms such as psychosis, anxiety, and depression are often linked: Take steps to clear out electronics and other disturbances in the bedroom. Melatonin, chamomile tea, and other supplementation can help improve sleep quality and duration. Get a correctly-shaped pillow, comfortable mattress, and some black-out curtains, comfortable light-blocking eye protectors that may also help.2,23,44,45,46,47,49
  • Caffeine and other stimulants: should be avoided at least 6 hours before bedtime, and strictly eliminated if insomnia, anxiety, or mania are issues of concern.48
  • Avoid personal care products with neurotoxic components: including everything from cosmetics to cleaning products, off-gassing paint, and furniture, “air fresheners” in the home and workplace. These are important to avoid, especially as potentially thousands of chemicals may be causing havoc, especially as they are apt to be contacted daily, and over long periods of time.42
  • Quit recreational use of alcohol, cannabis, cocaine. These and other drugs, even if prescribed, can induce symptoms resembling psychosis and mania, especially over long-term use. 6-8,12

Many safe alternatives to support natural mental health, such as those in the above list, are within easy grasp. Alternative to Meds Center has developed an amazing array of safe alternatives to Fanapt and similar drugs. Please contact us directly to find out more information about how these alternative treatments are used in-patient for our clients.

What Kinds of Things Commonly Trigger Psychotic Episodes?

gut microbiome brain connectionSome of the most common reasons for triggering an episode of psychosis range from experimenting with recreational drugs, to suddenly stopping drinking alcohol after long-term use, to being exposed to some kind of environmental toxin, and even to medical conditions. Usually, the causes for a sudden psychotic episode are the last thing on anyone’s mind when in the middle of such a crisis. But after the crisis has somewhat settled, this is an optimum time to start looking for those underlying reasons.

Once some of the potential culprits are discovered, these can be addressed for long-term and sustainable relief of symptoms. Importantly, many of these could be classified as medical conditions.

Some of the most documented triggers for psychosis and other psychiatric symptoms are:

  • Mercury, lead, or other types of toxic exposures causing neurological dysfunction4
  • Dehydration 9
  • Low levels of sodium in the blood 10
  • Toxic molds in living quarters or workplace 11
  • Recreational drug use, i.e., cannabis, cocaine, etc.6,7
  • Prescribed drugs, i.e., Prozac®, Digoxin®, or others which may induce psychosis/ agitation/ violent mood swings, hallucinations, etc.1,8
  • Alcohol withdrawal 12
  • Exposure to environmental toxins, chemicals in cleaners and solvents, arsenic, may cause acute psychosis and other psychiatric symptoms.5
  • Sleep deprivation, prolonged sleep loss 2
  • Nutritional deficiencies especially Vit D and to a limited extent Vit C, etc.13
  • Psychological stress, trauma 14
  • Medical conditions such as high or low blood sugar and diabetes 3

Pronouncement of a Mental Illness Does Not Equal a Cure

fanapt alternativesIt is well documented that physicians are in the vast majority trying their best to help their patients. However, let us remember that pronouncing a mental disorder label does not actually fix what is wrong. As in the case of so many of our clients at Alternative to Meds Center, once the reason for the psychosis was discovered, after addressing those cause(s), the label becomes redundant. Correcting the diet, removing neurotoxins from the body, reducing stress levels through psychological counseling, and other actions are much more important and could be absolutely critical to the recovery (tapering and withdrawal) process after antipsychotic medications.

A not uncommon example, a person can go into a hallucinatory state due to crashing blood sugar levels.3 Consequently, the problem will never be factually corrected by sedating the person with Fanapt or other drugs just to make their symptoms invisible. However, the underlying medical condition, hypoglycemia, would also remain invisible and would continue to put the person at risk both mentally and physically. We must always search for underlying causes and treat them properly when they are discovered.

Find Out More About Alternative to Meds Center

Call us for more information about the thorough testing and treatment programs the center offers, and how we support natural mental health. Fanapt alternatives delivered in a compassionate, pristine inpatient setting under medical supervision could be the answer you or a loved one has been needing to find for a long time.


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2. Heavner W, “Why do humans hallucinate on little sleep?” Wu Tsai Neurosciences Institute, Stanford University [Internet] 2016 Feb 19 [cited 2021 Nov 24]

3. Sahoo S, Mehra A, Grover S, Acute Hyperglycemia Associated With Psychiatric Symptoms in a Patient with Diabetes Mellitus: A Case Report. Innovations in Clinical Neuroscience [INTERNET] 2016 Nov/Dec [cited 2021 Nov 24]

4.  Oz SG, Tozlu M, Yalcin SS, Sozen T, Guven GS. Mercury vapor inhalation and poisoning of a family. Inhal Toxicol. 2012 Aug;24(10):652-8. doi: 10.3109/08958378.2012.708677. PMID: 22906171. [cited 2021 Nov 24]

5.  Wu HE, Abdel-Gawad NM, Gharbaoui Y, Teixeira AL, Pigott TA. An Unusual Case of Acute Psychosis With Obsessive-Compulsive Features Following Arsenic Poisoning. J Psychiatr Pract. 2017 Sep;23(5):382-385. doi: 10.1097/PRA.0000000000000254. PMID: 28961669.[cited 2021 Nov 24]

6.  Brady KT, Lydiard RB, Malcolm R, Ballenger JC. Cocaine-induced psychosis. J Clin Psychiatry. 1991 Dec;52(12):509-12. PMID: 1752853.[cited 2021 Nov 24]

7.  Shah D, Chand P, Bandawar M, Benegal V, Murthy P. Cannabis induced psychosis and subsequent psychiatric disorders. Asian J Psychiatr. 2017 Dec;30:180-184. doi: 10.1016/j.ajp.2017.10.003. Epub 2017 Oct 16. PMID: 29096386. [cited 2021 Nov 24]

8.  Dording CM, Sinicropi-Yao L, Papakostas G, Matthews JD, Nierenberg AA, Fava M, Mischoulon D. The response of psychotic-like symptoms to fluoxetine monotherapy in non-psychotic major depressive disorder. Nord J Psychiatry. 2009;63(5):420-5. doi: 10.1080/08039480903015396. PMID: 19521922. [cited 2021 Nov 24]

9.  Zhang N, Du SM, Zhang JF, Ma GS. Effects of Dehydration and Rehydration on Cognitive Performance and Mood among Male College Students in Cangzhou, China: A Self-Controlled Trial. Int J Environ Res Public Health. 2019 May 29;16(11):1891. doi: 10.3390/ijerph16111891. PMID: 31146326; PMCID: PMC6603652. [cited 2021 Nov 24]

10.  Giuliani C, Peri A. Effects of Hyponatremia on the BrainJ Clin Med. 2014;3(4):1163-1177. Published 2014 Oct 28. doi:10.3390/jcm3041163 [cited 2021 Nov 24]

11.  Empting LD. Neurologic and neuropsychiatric syndrome features of mold and mycotoxin exposure. Toxicol Ind Health. 2009 Oct-Nov;25(9-10):577-81. doi: 10.1177/0748233709348393. PMID: 19854819. [cited 2021 Nov 24]

12.  Mainerova B, Prasko J, Latalova K, Axmann K, Cerna M, Horacek R, Bradacova R. Alcohol withdrawal delirium – diagnosis, course and treatment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Mar;159(1):44-52. doi: 10.5507/bp.2013.089. Epub 2013 Dec 11. PMID: 24399242.[cited 2021 Nov 24]

13.  Firth J, Carney R, Stubbs B, Teasdale SB, Vancampfort D, Ward PB, Berk M, Sarris J. Nutritional Deficiencies and Clinical Correlates in First-Episode Psychosis: A Systematic Review and Meta-analysis. Schizophr Bull. 2018 Oct 17;44(6):1275-1292. doi: 10.1093/schbul/sbx162. PMID: 29206972; PMCID: PMC6192507. [cited 2021 Nov 24]

14.  van Winkel R, Stefanis NC, Myin-Germeys I. Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction. Schizophr Bull. 2008;34(6):1095-1105. doi:10.1093/schbul/sbn101[cited 2021 Nov 24]

15.  Ward M, Druss B. The epidemiology of diabetes in psychotic disorders. Lancet Psychiatry. 2015 May;2(5):431-451. doi: 10.1016/S2215-0366(15)00007-3. Epub 2015 Apr 28. PMID: 26360287. [cited 2021 Nov 24]

16.  Sahoo S, Mehra A, Grover S. Acute Hyperglycemia Associated with Psychotic Symptoms in a Patient with Type 1 Diabetes Mellitus: A Case Report. Innov Clin Neurosci. 2016 Dec 1;13(11-12):25-27. PMID: 28210522; PMCID: PMC5300708. [cited 2021 Nov 24]

17.  FDA label Fanapt (iloperidone) tablets  [cited 2021 Nov 24]

18.  Maglione M, Maher AR, Hu J, Wang Z, Shanman R, Shekelle PG, Roth B, Hilton L, Suttorp MJ, Ewing BA, Motala A, Perry T. Off-Label Use of Atypical Antipsychotics: An Update [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Sep. Report No.: 11-EHC087-EF. PMID: 22132426. [cited 2021 Nov 24]

19.  McKean A, Monasterio E. Off-label use of atypical antipsychotics: cause for concern? CNS Drugs. 2012 May 1;26(5):383-90. doi: 10.2165/11632030-000000000-00000. PMID: 22448598. [cited 2021 Nov 26]

20.  Maher AR, Theodore G. Summary of the comparative effectiveness review on off-label use of atypical antipsychotics. J Manag Care Pharm. 2012 Jun;18(5 Suppl B):S1-20. doi: 10.18553/jmcp.2012.18.s5-b.1. PMID: 22784311.[cited 2021 Nov 26]

21.  Aberle D, Wu SE, Oklu R, Erinjeri J, Deipolyi AR. Association Between Allergies and Psychiatric Disorders in Patients Undergoing Invasive Procedures. Psychosomatics. 2017 Sep-Oct;58(5):490-495. doi: 10.1016/j.psym.2017.03.015. Epub 2017 Mar 28. PMID: 28527521 [cited 2021 Nov 26]

22. Kiecolt-Glaser, Janice K. “Stress, Food, and Inflammation: Psychoneuroimmunology and Nutrition at the Cutting Edge.” Psychosomatic Medicine 72, no. 4 (May 2010): 365–69. https://doi.org/10.1097/PSY.0b013e3181dbf489 [cited 2021 Nov 26]

23.  Lakhan, Shaheen E and Vieira, Karen F “Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review,” summary of 24 clinical trials, AMJ, US National Lib.of Medicine [2009 Sept] PMID 20919532 [Internet] 2010 Oct [cited 2021 Nov 26]

24.    “CBT Better than Medication For Treating Social Anxiety Disorder.” The Psychiatry Advisor [Internet] 2014 Sep 26 [cited 2021 Nov 26]

25.  Stallones L, Beseler CL. Assessing the connection between organophosphate pesticide poisoning and mental health: A comparison of neuropsychological symptoms from clinical observations, animal models and epidemiological studies. Cortex. 2016 Jan;74:405-16. doi: 10.1016/j.cortex.2015.10.002. Epub 2015 Oct 28. PMID: 26654853.[cited 2021 Nov 26]

26.  Sánchez-Santed F, Colomina MT, Herrero Hernández E. Organophosphate pesticide exposure and neurodegeneration. Cortex. 2016 Jan;74:417-26. doi: 10.1016/j.cortex.2015.10.003. Epub 2015 Oct 20. PMID: 26687930. [cited 2021 Nov 26]

27.  Lachance L, Ramsey D. Food, mood, and brain health: implications for the modern clinician. Mo Med. 2015;112(2):111-115. [cited 2021 Nov 26] 

28.  Wani, Ab Latif, Sajad Ahmad Bhat, and Anjum Ara. “Omega-3 Fatty Acids and the Treatment of Depression: A Review of Scientific Evidence.” Integrative Medicine Research 4, no. 3 (September 2015): 132–41. https://doi.org/10.1016/j.imr.2015.07.003 [cited 2021 Nov 26]

29.  Lindseth, Glenda, Brian Helland, and Julie Caspers. “The Effects of Dietary Tryptophan on Affective Disorders.” Archives of Psychiatric Nursing 29, no. 2 (April 2015): 102 [cited 2021 Nov 26]

30.  Savage KM, Stough CK, Byrne GJ, et al. Kava for the treatment of generalised anxiety disorder (K-GAD): study protocol for a randomised controlled trial. Trials. 2015;16:493. Published 2015 Nov 2. doi:10.1186/s13063-015-0986-5. [cited 2021 Nov 26]]

31.  Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review.Front Neurosci. 2020;14:923. Published 2020 Sep 17. doi:10.3389/fnins.2020.00923. [cited 2021 Nov 26]

32.  Jakaria M, Azam S, Haque ME, et al. Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms. Redox Biol. 2019;24:101223. doi:10.1016/j.redox.2019.101223. [cited 2021 Nov 26]

33.  Hoge, Elizabeth A., Eric Bui, Luana Marques, Christina A. Metcalf, Laura K. Morris, Donald J. Robinaugh, John J. Worthington, Mark H. Pollack, and Naomi M. Simon. “Randomized Controlled Trial of Mindfulness Meditation for Generalized Anxiety Disorder: Effects on Anxiety and Stress Reactivity.” The Journal of Clinical Psychiatry 74, no. 8 (August 2013): 786–92. https://doi.org/10.4088/JCP.12m08083. [cited 2021 Nov 26]

34.  Gu, Jenny, Clara Strauss, Rod Bond, and Kate Cavanagh. “How Do Mindfulness-Based Cognitive Therapy and Mindfulness-Based Stress Reduction Improve Mental Health and Wellbeing? A Systematic Review and Meta-Analysis of Mediation Studies.” Clinical Psychology Review37 (April 1, 2015): 1–12. https://doi.org/10.1016/j.cpr.2015.01.006 [cited 2021 Nov 26]

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36.  Choudhary AK, Lee YY. Neurophysiological symptoms and aspartame: What is the connection? Nutr Neurosci. 2018 Jun;21(5):306-316. doi: 10.1080/1028415X.2017.1288340. Epub 2017 Feb 15. PMID: 28198207. [cited 2021 Nov 26]

37.  Craft, Lynette L., and Frank M. Perna. “The Benefits of Exercise for the Clinically Depressed.” Primary Care Companion to The Journal of Clinical Psychiatry 6, no. 3 (2004): 104–11. [cited 2021 Nov 26]

38.  Kondo, Michelle C., Sara F. Jacoby, and Eugenia C. South. “Does Spending Time Outdoors Reduce Stress? A Review of Real-Time Stress Response to Outdoor Environments.” Health & Place51 (May 1, 2018): 136–50. https://doi.org/10.1016/j.healthplace.2018.03.001[cited 2021 Nov 26]

39.  Capaldi, Colin A., Raelyne L. Dopko, and John M. Zelenski. “The Relationship between Nature Connectedness and Happiness: A Meta-Analysis.” Frontiers in Psychology 5 (2014). https://doi.org/10.3389/fpsyg.2014.00976 [cited 2021 Nov 26]

40.  Rea WJ, Didriksen N, Simon TR, Pan Y, Fenyves EJ, Griffiths B. Effects of toxic exposure to molds and mycotoxins in building-related illnesses. Arch Environ Health. 2003 Jul;58(7):399-405. doi: 10.1080/00039896.2003.11879140. PMID: 15143852. [cited 2021 Nov 26]

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46.  Shechter A, Kim EW, St-Onge MP, Westwood AJ. Blocking nocturnal blue light for insomnia: A randomized controlled trial. J Psychiatr Res. 2018 Jan;96:196-202. doi: 10.1016/j.jpsychires.2017.10.015. Epub 2017 Oct 21. PMID: 29101797; PMCID: PMC5703049. [cited 2021 Nov 26]

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Originally Published Mar 23, 2020 by Diane Ridaeus


This content has been reviewed and approved by a licensed physician.

Dr. Samuel Lee

Dr. Samuel Lee is a board-certified psychiatrist, specializing in a spiritually-based mental health discipline and integrative approaches. He graduated with an MD at Loma Linda University School of Medicine and did a residency in psychiatry at Cedars-Sinai Medical Center and University of Washington School of Medicine in Seattle. He has also been an inpatient adult psychiatrist at Kaweah Delta Mental Health Hospital and the primary attending geriatric psychiatrist at the Auerbach Inpatient Psychiatric Jewish Home Hospital. In addition, he served as the general adult outpatient psychiatrist at Kaiser Permanente.  He is board-certified in psychiatry and neurology and has a B.A. Magna Cum Laude in Religion from Pacific Union College. His specialty is in natural healing techniques that promote the body’s innate ability to heal itself.

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