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tapering off trintellix

Trintellix Tapering

If Trintellex, an atypical antidepressant did not yield the desired results, you may be considering Trintellix tapering as the next step of your overall health plan. The antidepressant Trintellix is intended only as a prescription antidepressant when other antidepressants have not worked, rather than a first-line treatment choice. (1) This would probably mean that a person taking Trintellix had tapered off another antidepressant medication before starting to take Trintellix. Perhaps this process went smoothly, or perhaps it did not go as easily as hoped. Withdrawal from Trintellix, as is the case with many drugs, can be difficult without good planning and excellent guidance. It is always advisable to be aware of FDA recommendations, information, and cautions regarding starting and stopping Trintellix or other prescription drug treatments.

In general, there are two main reasons people might consider stopping Trintellix or other types of medication. One is that the drug possibly did not bring the relief that was hoped for, as mentioned above. The results and improvements might have been less than expected. In the case of Trintellix in particular, the drug is FDA approved only for the treatment of MDD, and only when other drugs have not worked in prior treatment. However, sometimes the lines become blurred when it comes to selecting a particular drug or class of drugs for treatment. Sometimes this results in “off label” prescribing and is a little like experimenting outside the lines as laid down in published FDA-approved, drug manufacturer recommendations. The results can be unpredictable and may lead to somewhat desperately trying to quit Trintellix as quickly as possible so that another drug can be introduced. (1)

The second reason is that the side effects of the drug became intolerable, and the need for withdrawal from Trintellix became acutely observable. This is a very common reason a person may desire getting off Trintellix. Since starting to take the drug, various side effects may have emerged which made continuing the drug therapy uncomfortable or even intolerable to continue. It may be helpful if you find yourself in this type of situation to realize that others have experienced similar problems, and you are not alone.

In either circumstance, this scenario could have repeated multiple times, switching from drug to drug, trying to quit Trintellix or another drug to avoid side effects such as nausea, headaches, diarrhea, sexual dysfunction, insomnia, or others. This is a potentially frustrating and sometimes scary difficulty to find oneself in. More information on specific and common Trintellix side effects can be found below.

Depression as a Diagnosed Mental Illness

Depression is classified in the DSM (diagnostic manual) as a disease that has some or all of the following characteristics: depressed mood, thoughts about suicide or death, sadness, hopelessness, fatigue, loss of interest generally in life including loss of interest in sex, sleep disturbances such as insomnia or sleeping too much, increased or decreased appetite, significant weight loss when not dieting, prolonged irritability, anger, persisting unexplained aches and pains, anxiety, agitation, cognitive impairment sometimes called “brain fog”, inability to concentrate, think clearly or quickly, inability to make decisions, slowed body movements, and other unwanted conditions. So if taking a drug such as Trintellix did not provide relief for these types of symptoms, it might be time to consider how to get off Trintellix and try other approaches, as opposed to other drugs, to address the problem. Other approaches to finding relief from these types of symptoms are further discussed below in this article.

The Alternative to Meds Center has helped many people to extricate themselves from such a tangle of methods of treatment that were not as effective as one had hoped. How to get off Trintellix safely and gently is a subject that deserves careful consideration. Our treatment plans are based on testing and the discovery and treatment of root causes. We do not believe that simply masking symptoms results in optimum treatment results. Trying to quit Trintellix (and other medications) does not have to introduce further complications or harsh symptoms. We specialize in safely stopping Trintellix as well as other medications, as a first step, and with great success. More on our Trintellix cessation protocols can be found below.

trintellix tapering

Trintellix Side Effects

According to the drug manufacturer, the most commonly reported side effects for Trintellix include nausea, constipation, and vomiting. Other more severe side effects that consumers and caregivers are advised to watch for while taking Trintellix include suicide attempts, suicidal thoughts, serotonin syndrome, violent behavior, akathisia, worsened depression, mania, hypomania, trouble sleeping, drop-in sodium blood levels, and many others. (2)

These are not dissimilar from the side effects of virtually all other antidepressants on the market. Such side effects can be difficult to tolerate and may make this type of treatment unworkable. It is possible that getting off Trintellix can open the door to other, non-drug-based treatments, that may be more effective at helping you reach your health goals.

Cautions Regarding Trintellix and Pregnancy

The drug manufacturer indicates that if Trintellix is taken during the last trimester of pregnancy, the baby may be born with a condition known as PPHN, which means persistent pulmonary hypertension of the newborn, a persistent breathing difficulty. (3) This may be another very good reason to consider Trintellix tapering for a woman who is planning to become pregnant, and who wants to avoid potential birth complications for the infant.

Special Notes About the Name “Trintellix”

Trintellix is one of a group of relatively new antidepressant medications that have been on the market since 2013. Trintellix was first called Brintellix. However, a number of instances were reported where Brintellix was confused with another similar-sounding but entirely different drug, one that was used for anti-blood-clotting. In 2016 the drug manufacturer changed the name of Brintellix, the antidepressant, to Trintellix to avoid more instances of this confusion in the future.

How to Get Off Trintellix Safely

The Alternative to Meds Center offers a Trintellix tapering program done gradually and comfortably over a two month period of time. Longer programs can easily be arranged if desired. Clients are under the care of our licensed doctors, integrative psychiatrist, nursing staff, and clinicians who are all familiar with the intricacies of getting off Trintellix or other medications comfortably and safely.

The program features many components to support and even soften Trintellix tapering. Some of these include testing for accumulations of neurotoxins, removal of these toxic substances through gentle cleansing methods, testing for and correcting vitamin and mineral deficiencies, low-temperature sauna, comforting mineral baths, refreshing foot baths, therapeutic massage, mild trainer-led exercise, yoga, meditation, nebulized glutathione treatments, bentonite clay packs, acupuncture, acupressure, colonics, and many other gentle adjunctive procedures that are designed to considerably ease the Trintellix tapering process. Done in this way, Trintellix tapering can be surprisingly mild and easy to tolerate.

Counseling is also offered, along with life coaching, that can help a person regain balance and renewed positive energy for life. Equine-assisted therapy, music therapy, and art therapy are also offered and are very popular with our clients.

Understanding how the CNS (central nervous system), hormones, brain chemistry, microbiome, and other important health matters are all interconnected can greatly assist a person who is getting off Trintellix with tools and practical approaches for self-care once they leave the program. The Alternative to Meds Center provides a comprehensive educational module that covers these and other related topics to empower the client with practical and useful information. Withdrawal from Trintellix does not have to be torturous or difficult when done in a truly caring and compassionate inpatient setting, with 24/7 staff on hand throughout the process.

Find Out More About the Trintellix Tapering Program at the Alternative to Meds Center

Please contact us at the Alternative to Meds Center, to find out much more detailed information about our Trintellix tapering programs at the center, and how you or your loved one may benefit from the services we provide to address root causes and thereby improve mental health naturally.

  1. Trintellix – New Once Daily Antidepressant With a Unique Multi-Modal Mechanism of Action, Claimsecure Drug Review Vol XIV, Issue 1 [INTERNET]  [cited June 5, 2020] 

  2. Trintellix Medication Label Update, Takeda website [INTERNET] May 2, 2018 [cited June 5, 2020]  

  3. Medication Guide Trintellix (vortioxetine) published by Takeda Pharmaceuticals America, approved by the US Food & Drug Administration [April 2017]  [cited June 5, 2020] 


This content has been reviewed and approved by a licensed physician.

Dr. Samuel Lee

Dr. Samuel Lee is a board-certified psychiatrist, specializing in a spiritually-based mental health discipline and integrative approaches. He graduated with an MD at Loma Linda University School of Medicine and did a residency in psychiatry at Cedars-Sinai Medical Center and University of Washington School of Medicine in Seattle. He has also been an inpatient adult psychiatrist at Kaweah Delta Mental Health Hospital and the primary attending geriatric psychiatrist at the Auerbach Inpatient Psychiatric Jewish Home Hospital. In addition, he served as the general adult outpatient psychiatrist at Kaiser Permanente.  He is board-certified in psychiatry and neurology and has a B.A. Magna Cum Laude in Religion from Pacific Union College. His specialty is in natural healing techniques that promote the body’s innate ability to heal itself.

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