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Antidepressants Provigil Withdrawal

Antidepressant medications generally are administered prior to any substantial medical investigations or lifestyle interventions, and almost no consideration of what Provigil withdrawal might look like.

Depression can be the result of impaired hormonal states, deficiency of vitamin D, substandard diet, adrenal fatigue, lack of exercise, failed life aspirations, and other factors other than a medication deficiency.

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Alternative to Meds has been primarily invested in medication withdrawal for over 15 years. Using Holistic and Environmental Medicine, we have published evidence demonstrating that over 77% of people discontinuing antidepressant medication and replacing them with a holistic lifestyle perform symptomatically better than they were while medicated.
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About Provigil® Withdrawal

When a person is experiencing Provigil withdrawal symptoms, they are likely going to experience overstimulation, insomnia or sleep disturbances, anxiety, and possibly Tourette’s and OCD like symptoms. Since this withdrawal has the potential to be quite serious, it is important to seek medical attention if you are using this drug more than prescribed, for non-medical purposes, or if you want to stop taking it safely. Never stop any antidepressant medication abruptly.1,3

About Provigil Risks

Provigil is a medication that is generally prescribed to promote wakefulness; it is a central nervous system stimulant that can create feelings of euphoria and can encourage users to abuse it to achieve the “high” it produces. Along with the potential dangers of Provigil abuse and dependence, withdrawal side effects are also possible when stopping the medication. Provigil is also specifically approved for the treatment of excessive sleeping associated with narcolepsy, sleep apnea, and SWSD (shift work sleep disorder). SWSD is a problem in individuals who work late night shifts or frequently change back and forth between night and day work shifts. This medication is considered to be a controlled substance, meaning that is has a potential for abuse. Naturally, any substance that you can become addicted to physically and/or psychologically, can also yield withdrawal symptoms when it is removed from the person’s system. This medication does not cure narcolepsy, sleep apnea or shift work sleep disorder. Thus, when use is discontinued, symptoms of these conditions are likely to return; and in much-worsened states.

Provigil Dependence Risk

There is research on abuse of Provigil, which in animal studies, propose that this drug can be abused. In animal research studies, monkeys that had been previously accustomed to administering cocaine to themselves also self-administered Provigil when they were given the chance. This indicates that this drug is “reinforcing,” which means it provides effects or feelings that persuade its repeated use. Prior to the approval of medications, there are special studies done to identify if there is an indication that the drug has the potential of being abused. Because animal studies suggest that it does have abuse potential, this drug also was studied in humans with histories of drug abuse. The results of this study showed that Provigil created effects (including euphoria) similar to other abused stimulants. Moreover, in order to effectively lessen or avoid Provigil side effects of withdrawal, one should seek Provigil withdrawal help for safe, gradual cessation.2

provigil withdrawal

Why do symptoms of antidepressant withdrawal occur from stopping Provigil?

Serotonin deficiency (a frequently theorized cause of depression), even if not present before taking antidepressant medications, can develop from taking them. These medications do not create serotonin, but they block it from reuptake. It is meant for reuptake, so the serotonin can be reused by the nerve cell. This is a conservative process.

However, if the serotonin is kept in the nerve space (synapse), it is corrupted into metabolites, and there is then no more serotonin left for reuptake. This is all very similar to the way cocaine only temporarily relieves the feeling of depression. Similarly, cocaine uses up all of the dopamine, which is the reward neurochemical, cocaine does not create it. Everything seems rewarding when a person first takes cocaine. But at some point, all the dopamine is gone and then nothing holds any value to the person.

We Provide Natural Alternatives

Our program at Alternative to Meds Center discovers the medical reasons why an individual may be suffering from physical or mental health conditions. The process also includes lab testing, use of natural substances to stabilize neurochemistry, medication withdrawal methods, detoxification of accumulated toxins, nutritional therapy, massage therapy, yoga, personal exercise training, peer support, and other healing therapies to protect against uncomfortable withdrawal symptoms. We provide comprehensive plans for Provigil withdrawal help. You are invited to give us a call anytime to learn more about the Provigil withdrawal help that our drug treatment facility has available.


1. FDA Provigil (Modafinil) label [cited 2019 Oct].

2. Kim D “Practical Use and Risk of Modafinil” NIMH article, US National Library of Medicine, 2012 Feb [cited 2019 Oct].

3. Harvard Medical Publishing, “What are the real risks of antidepressants?” updated 2019 Mar [internet] [cited 2019 Oct].



This content has been reviewed and approved by a licensed physician.

Dr. Samuel Lee

Dr. Samuel Lee is a board-certified psychiatrist, specializing in a spiritually-based mental health discipline and integrative approaches. He graduated with an MD at Loma Linda University School of Medicine and did a residency in psychiatry at Cedars-Sinai Medical Center and University of Washington School of Medicine in Seattle. He has also been an inpatient adult psychiatrist at Kaweah Delta Mental Health Hospital and the primary attending geriatric psychiatrist at the Auerbach Inpatient Psychiatric Jewish Home Hospital. In addition, he served as the general adult outpatient psychiatrist at Kaiser Permanente.  He is board-certified in psychiatry and neurology and has a B.A. Magna Cum Laude in Religion from Pacific Union College. His specialty is in natural healing techniques that promote the body’s innate ability to heal itself.

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