Amitriptyline Side Effects

Amitriptyline Side Effects

Amitriptyline side effects are similar to those of many other drugs in the antidepressant class. Some differences set this TCA (tricyclic antidepressant) drug apart from others.


Researchers have studied these drugs and how drugmakers theorize the ways that they work in general. Studies have helped to discover some adverse effects linked to tricyclics such as amitriptyline in particular. 

How Does the Antidepressant Amitriptyline Work? 

Drugs like amitriptyline block three receptors, hence the description of the drug as a "tricyclic" agent: the muscarinic, alpha 1 adrenergic and histamine H1 receptors, that lie along nerve pathways. These receptors have specific and varied functions along the chemical/nerve pathways and are designed to act and respond in specific ways.   Much more research needs doing in this regard. But it is conjectured by studies already done that Amitriptyline disrupts or blocks these receptors, and in so doing, can cause adverse effects relating to those specific sites, including (but not limited to) the following: 

  • Blurred vision
  • Narrow-angle glaucoma (type of degenerative eye disease leading to loss of vision)
  • Xerostomia (an abnormal lack of saliva in the mouth)
  • Urinary retention
  • Constipation
  • Postural hypotension (change in blood pressure when changing posture from sitting/laying to standing up)
  • Dizziness
  • Reflex tachycardia (increase in heart rate due to some stimulus to the heart nerves- note that when the heart rate is above 100 in adults, the heart pumps less efficiently, meaning less blood flows out to the rest of the body, despite the higher rate of heart pumping.)
  • Sedation

Antidepressants in General Double the Risk of Suicide

Antidepressants have been documented to double the risk of suicidal thinking and behaviors. There are multiple other adverse effects linked to antidepressants that make a far longer list, and these include: anxiety, lowered sex drive, weight gain, daytime tiredness, insomnia, excessive sweating (especially at night), tremors, heart palpitations, and seizures. 

Antidepressants vs. Placebo

There has been much discussion since the studies done in the 1990s that demonstrated that all patients in the trial (except a very few who were extremely depressed)  received virtually the same benefits as the patients in the trials who took a placebo (i.e., a sugar pill, non-psychoactive pill, etc.).  Drugmakers sought to discount or discredit these results but were unable to do so. One can draw one's own conclusions about the pharmaceutical industry when viewing results of studies of thousands of patients like the above-mentioned ones. 

Adverse Effects of Medications vs. Alternative Therapies for Depression

In the modern age of wellness and alternative therapies today, there are many options for treating conditions such as depression. At the Alternative to Meds Center, we utilize many different non-invasive and drug-free protocols that help normalize physical and mental health. 

Where a client has already begun a prescription of antidepressant medication, we also offer a safe and gentle Amitriptyline withdrawal program so that as they rebuild their health and obtain improvements in energy, mood, and emotional well-being, the client can successfully get off their medications and say goodbye to their adverse effects.

Where to Find Drug-Free Help for Depression 

Contact the Alternative to Meds Center for information on how our programs might provide the answers for which you may have been looking. Treating depression naturally without the need for prescription drugs is possible in our program. Call today to find out more, and to see how enrolling in our residential program could help you or your loved one overcome emotional challenges, without dangerous and troubling amitriptyline side effects.


Antidepressant Withdrawal Success Video

Susan's Success Story

Watch the video of how Susan was so debilitated by medications, anxiety, depression and poor health that she could barely leave her house. Follow her amazing story through treatment, and back ...

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